Alpha-(1,6)-fucosyltransferase (FUT8) is the sole enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis. Here we find that multiple viral envelope proteins, including Hepatitis C Virus (HCV)-E2, Vesicular stomatitis virus (VSV)-G, Severe acute ...
The core trisaccharide building block was protected by a methoxyphenyl group for convenient core fucosylation. The trisaccharide was obtained on a large scale from the glycosylation of the corresponding chitobiosyl azide with a glucosyl donor followed by intramolecular inversion. Improved methods were ...
1) core fucosylation 核心岩藻糖基化1. The expression of α-1,6FucT gene (FUT8) in SMMC-7721 cells was assayed by semiquantitative RT-PCR and core fucosylation levels on substrates were detected by lens culinaris agglutinin (LCA) blotting. 方法 通过对SMMC- 772 1细胞分别按不同时间点和不...
Aberrant N-glycosylation has been implicated in viral diseases. Alpha-(1,6)-fucosyltransferase (FUT8) is the sole enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis. Here we find that multiple viral envelope proteins,
Core fucosylation of N-linked glycoproteins has been linked to the functions of glycoproteins in physiological and pathological processes. However, quantitative characterization of core fucosylation remains challenging due to the complexity and heterogen
Core-fucosylation of proteins has been reported to be involved in many tumor processes, such as HCC, pancreatic cancer, lung cancer and ovarian cancer36,37,38,39. In our study, mutant QSOX1 showed a glycan depletion at Asn-130 residue, instead of only a depleted core-fucose attached on ...
New wrinkles in old receptors: core fucosylation is yet another target to inhibit TGF-β signaling. Kidney Int 84: 11-14. Venkatachalam,A M.,Weinberg,... - 《Kidney International Official Journal of the International Society of Nephrology》 被引量: 0发表: 2013年 From The Cover: Dysregulation...
α1–6(α1–3)-Difucosylation of the asparagine-bound N -acetylglucosamine in honeybee venom phospholipase A 2 1992. α1-6(α 1-3)-difucosylation of the asparagine-bound N-acetylglucosamine in honeybee venom phospholipase A2. Glycoconj J. 9: 82-85... ...
transition in RIF. The down-regulation of core fucosylation prevented the pericyte transition and RIF by inhibiting the activities of both the TGF-β/Smad and PDGF/ERK pathways. This study is the first to suggest that the core fucosylation of pericytes represents a promising “hub” target for ...
No other glycosyltransferase has been found to be equipped with this domain, suggesting that the SH3 domain in FUT8 specifically regulates FUT8 functions, such as core fucosylation activity, subcellular localization, and/or interaction with other molecules. In this study, by using mutant FUT8 ...