Core transcription regulatory circuitry orchestrates corneal epithelial homeostasisHOMEOSTASISEPITHELIAL cellsGENE regulatory networksPROGENITOR cellsSTEM cellsCIS-regulatory elements (Genetics)CHROMATINAdult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-restricted epigenetic and ...
[5,6]. Such a pluripotent transcriptional regulatory network nurtured the model/concept of core transcriptional regulatory circuitry (CRC) in ESCs [7]. Apart from core TFs, additional layers of core regulators have been discovered and integrated into the pluripotent transcription circuitry including ext...
Transcription Factor Core Regulatory Circuitry of CLL With the goal of understanding the critical TF interactions responsible for maintaining the CLL transcriptional program, we modeled transcriptional regulatory networks mediated by asymmetrically large enhancer domains. We utilized H3K27ac domains to define...
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 38, 431–440 (2006). Article CAS Google Scholar Boyer, L.A. et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122, 947–956 (2005). Article CAS ...
TP63, SOX2, and KLF5 establish a core regulatory circuitry that controls epigenetic and transcription patterns in esophageal squamous cell carcinoma cell l... TP63, SOX2, and KLF5 establish a core regulatory circuitry that controls epigenetic and transcription patterns in esophageal squamous cell ...
Thecorepluripotencycircuitryofembry- onicstemcells(ESCs)encompassesa smallnumberofverypotentkeymaster transcriptionregulatorsthatbindproximal anddistalregulatoryelementsoftran- scriptionregulators,signaltransduction components,andchromatin-modifying enzymesthatfacilitateESCself-renewal ...
There are comments on PubPeer for publication: TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines (2020)
Yang R, Sriram K, Doyle FJ: Control circuitry for fear conditioning associated with post-traumatic stress disorder (PTSD). IEEE Conference on Decision and Control (CDC): 15-17 Dec. 2010. 2010, Atlanta, USA: Institute of Electrical and Electronics Engineers Inc., 2541-2546. Chapter Google Sch...
While some investigators have proposed that lncRNAs mainly represent the product of leaky transcription [2], there is now considerable evidence indicating that deregulation of these molecules functionally drives physiological and pathological processes. As genetic mapping and functional characterization of ...
Core transcriptional regulatory circuitry (CRC) consists of autoregulated transcription factors (TFs) and their enhancers, which dominate gene expression programs and control cell fate. However, there is limited knowledge of CRC in TNBC. Herein, we systemically characterized the act...