Transcriptional regulatory elements are nucleotide sequences of a gene that are involved in regulation of genetic transcription. These include the promoter, plus response elements, activator and enhancer sequences for binding of transcription factors to aid RNA polymerase binding and promote expression, an...
TFs regulate gene expression by binding to distal enhancer elements and to promoters located close to the TSS8,9. Both enhancers and promoters are characterized by RNA transcription10, the presence of open chromatin11 and histone H3 lysine 27 acetylation (H3K27ac)12. In addition, promoters and...
The present invention relates to transcription regulatory elements (TREs) such as promoters, which may be used to express a transgene within a cell such as a mammalian cell. The invention further relates to polynucleotides and vectors comprising such transcription regulatory elements, which may be ...
Recurrence of Chromosome Rearrangements and Reuse of DNA Breakpoints in the Evolution of the Triticeae Genomes A basic helix-loop-helix transcription factor gene in 5AL junction was significantly restructured. Rye and wheat share the same position for the 4L break... W Li,GS Challa,H Zhu,......
The results show that transcription ofrosRundergoes complex regulation, in which several regulatory elements located in the upstream region and some regulatory proteins are engaged. These include an upstream regulatory element, an extension of the -10 element containing three nucleotides TGn (TGn-...
regulatory elements involved in secondary metabolite cluster regulation. Identification of elements regulating secondary metabolism could potentially provide a means of increasing production of beneficial metabolites, decreasing production of detrimental metabolites, aid in the identification of ‘silent’ natural ...
TF cistromes produced by ChIP-seq represent the genome-wide locations of TF-binding sites and potential cis-regulatory elements. To infer the gene regulatory characteristics of different TFs, we used the regulatory potential (RP) model10 to describe the relationships between TF cistromes and gene ...
Sequences required for full promoter activity were identified by transient transfections of normal and mutated promoters into a gammadelta , and necessary elements fall between -86 and +66 nt, relative to the major transcription start site. They include a cAMP responsive element (CRE) at -62, ...
DNA-binding motifs for NtcA and LexA were correctly identified. The relevance of transcriptional regulation of predicted cis elements was supported experimentally. 展开 关键词: phylogenetic footprinting transcription factor binding sites marine cyanobacteria ...
with evidence of stimulus and cell- type specificity in regulation of the TNF gene involving promoter and 30 untranslated region (UTR) elements.1–4 Recently, we highlighted a number of putative regulatory elements lying outside the promoter regions of these genes based on chromatin profiling for ...