The fidelity of transcription initiation is essential for accurate gene expression, but the determinants of start site selection are not fully understood. Rap1 and other general regulatory factors (GRFs) control the expression of many genes in yeast. We show that depletion of these factors induces...
What are transcription factors? What general transcription factor is most often affected by regulatory transcription factors? (a) TFIIF (b) TFIIE (c) TFIID (d) TFIIB. What controls the transcription of a gene? What are the key molecular components and genetic elements needed...
aThey bind regulatory proteins known as specific transcription factors, as opposed to the general transcription factors shared by all promoters that use RNA polymerase II 他们束缚管理蛋白质以具体副本因素著名,与使用RNA聚合酶II的所有促进者分享的一般副本因素相对[translate]...
Understanding gene expression will require understanding where regulatory factors bind genomic DNA. The frequently used sequence-based motifs of protein-DNA binding are not predictive, since a genome contains many more binding sites than are actually bound and transcription factors of the same family sha...
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576–589 (2010). Article CAS PubMed PubMed Central Google Scholar Kuo, C. C. et al. Detection of RNA–DNA binding sites in long non...
Explain what transcription factors and regulatory proteins are and how they regulate gene expression in eukaryotes. Describe two ways in which eukaryotes regulate gene expression inside of the nucleus and two ways in which they regulate gene expression outside o...
(i.e. extensive genomic upheavals), but posit that novel cell types or quasi-independent developmental modules are most likely to derive from a particular set of mutations: origin of new gene-regulatory sequences (e.g. from transposable elements), new transcription-factor functions, new ...
Control and patient pAstros were transduced with a retrovirus encoding either the red fluorescent protein dsRed alone, as a control, or together with the proneural transcription factors (TFs) Neurogenin-2 (Neurog2/Ngn2), Achaete-scute homolog 1 (Ascl1)4,5,21,22 or their phosphorylation-...
Early diagnosis of kidney cancer is one of the key factors in improving the survival rate of patients. Exosomes may benefit early diagnosis. Exosomes secreted by kidney cancer cells are abundantly present in blood, urine and other body fluids, thus providing advantages such as easy availability, ...
The asymmetric expression profiles of ASE left (ASEL) and ASE right (ASER) neurons is governed by the expression of two miRNAs, lys-6 and miR-273, that target distinct transcription factors controlling left vs right ASE neuron lineage-specific chemosensory receptor expression. Whereas miR-273 is...