FIELD: chemistry.;SUBSTANCE: method of converting alcohol containing an amide group into the corresponding carboxylic acid involves reaction of a primary amide alcohol of formula: R1-CONR2(CH2)mOH, where R1 is a linear or branched alkyl or alkenyl group, having 7-22 carbon atoms; R2 is H, ...
S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765) is an orally absorbed prodrug of (S)-3-({1-[(S)-1-((S)-2-{[1-(4-amino-3-chlorophenyl)...
O O O O OR R R H R OH R OR R NH2ketone aldehyde carboxylic acid ester amidein this chapter we will focus on the reactivity of ketones and aldehydesNomencla... - 《Phosgene》 被引量: 0发表: 1983年 Introduction to Aldehydes and Ketones A comparison of the properties and reactivity of...
1I, the C-terminus was covered by y-ions (y1, y2 and y5), and N-terminus was characterized by extended b-ion series (b1 and b2), indicating that the amide bond in the peptide bond was easily broken. As can been seen, b1 was concluded as Lys (K, m/z = 129), b2 was ...
Peptide and amide bonds may be formed by reacting 7 with a carboxylic acid halide or a mixed anhydride and a tertiary amine acid scavenger or alternatively by combining 7 and a carboxylic acid or protected amino acid with a wide variety of coupling reagents that are standard to the art of ...
Primary amide alcohol, it oxidizes this invention, to the amide carboxylic acid which corresponds it regards the method of being improved at high yield.ハリチアン,ビジヤンチエン,ハンローザ,ホセギレルモ
Amidebiocatalysiscarboxylic acidmolecular biologynitrilasenitrile hydrataseorganic synthesisNitrile-converting enzymes, including nitrilase and nitrile hydratase (NHase), have received increasing attention from researchers of industrial biocatalysis because of their critical role as a tool in organic synthesis of ...
Primary amide alcohol, it oxidizes this invention, to the amide carboxylic acid which corresponds it regards the method of being improved at high yield.ハリチアン,ビジヤンチエン,ハンローザ,ホセギレルモ
A process for converting an alcohol comprising an amide group to the corresponding carboxylic acid with a> = 75% yield, which process comprises reacting a primary amido alcohol of formula: R1-CONR2 (CH2) m OH wherein R1 is an alkyl group or straight or branched alkenyl having from 7 to ...
The invention provides a process for converting compounds comprising at least one nitrile function into compounds comprising at least one carboxylic function consisting of hydrating the nitrile functions in amide function by reacting with water in the presence of an acid. strong mineral, then hydrolyze...