While the impact of other driver gene mutations in AML is recognized, there is a lack of data on the actionable impact of those mutations.Nong, TiffanyMehra, ShefaliTaylor, JustinCells (2073-4409)
Acute myeloid leukemia (AML) is a genetically complex disease. Many different driver mutations are known to cause development of AML, moreover genetic and genomic features are the most important prognostic factors for overall survival [1]. In addition to cytogenetics, which have been pivotal in A...
In recent years, a trend toward single-cell analysis has shown thatindividual cellswithin atumorare capable of amassingmutationsto make them more aggressive and treatment resistant. So while 99% of a tumor may be destroyed by the initial treatment, a particularly aggressive cell can survive and ...
Mutations in normal somatic stem and progenitor cells leading to deregulation of their physiological programs is thought to increase their predisposition to tumor development. Under this cancer stem cell hypothesis viewpoint, the identification of genes commonly relevant to stem/progenitor cell and tumor ...
Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder caused by mutations in the NF1 gene. Patients with NF1 have a higher risk to devel... B.,V.,Balgobind,...
Overall, these results show that the assay is a versatile and specific tool for the screening of NPM1 mutations in patients with AML. Its high analytical sensitivity further suggests potential utility for the monitoring of residual disease in AML with normal karyotype.Michael...
2 Count Distribution and Pairwise Enrichments of Clonal Hematopoiesis of Indeterminate Potential (CHIP) Gene Mutations. A. Total number of individuals with mutations (y axis, log10 scale) in each of the 23 genes that were used to determine CHIP status across the UKB (blue) and GHS (red) ...
About 80% of RD have a genetic basis [2,3,4,5,6], resulting from mutations in an individual's genome that can be inherited through parental chromosomes [6]. Timely and accurate identification of RD is oftentimes dependent on multiple factors, such as the amount and variety of individual ...
The new generation of sequencing technologies opens up new possibilities for the analysis of the mutations in cancer owing to their high speed, relative low cost, and versatility to detect all types of genomic alterations. These methodologies are based on the fragmentation of ...
AML is diagnosed in 2,200 adults each year and it is thought that up to 10% of these cases are treatment-related. Leukaemia is often triggered by DNA mutations within white blood cells when part of one chromosome exchanges with part of another in a process called translocation. For these ...