9、急性全髓增殖伴骨髓纤维化 The category of acute myeloid leukaemia(AML), NOS, encompasses the cases that do not fulfil the criteria for inclusion in one of the previously described groups (i.e. AML with recurrent genetic abnormalities, myelodysplasia―r...
AML with recurrent genetic abnormalities, therapy―related myeloid neoplasms, or AML with myelodysplasia―related changes. 【翻译】那些满足伴重现性遗传学异常其它类型、治疗相关或伴骨髓增生异常相关改变的急性髓系白血病案例,不应诊断为AML伴RUNX1突变。 RU...
Recurrent genetic abnormalitiesFavorable riskFLT3mutationMolecular targeted therapyAcute myeloid leukemia (AML) is a heterogeneous disease characterized by various molecular abnormalities that significantly impact its pathogenesis and prognosis. Currently, the prognosis of AML patients is stratified on the basis ...
与15号染色体上的早幼粒细胞白血病(PML)基因发生融合,形成PML-RARα融合基因。 骨髓象 (4)M4(急性粒-单核细胞白血病) 细胞化学染色:POX、SB染色:原单和幼单细胞呈阴性或弱阳性反应,而幼粒细胞呈阳性或强阳性反应。 免疫学检测:白血病细胞主要表达粒、单系抗原CD13、CD14、CD33、HLA-DR,部分表达CD9。 染色体及...
and balanced abnormalities and excluded cases of therapy related AML and AML with recurrent genetic abnormalities, such as t(8;21), inv(3), and t(6;9), the latter two of which may have multilineage dysplasia [4]. Whether the presence of dysplastic morphologic features alone warrants classi ...
Despite recent advancements in the treatment of low- and intermediate-risk AML by targeting mutationally activated kinases49,50,51 and newer initial treatment options for a subset of patients52,53, high-risk AML with recurrent genetic abnormalities, such as inv(3)(q21.3q26.2) and t(3;3)(q...
Figure 2.AML with recurrent genetic abnormalities* AML, acute myeloid leukemia; APL, acute promyelocytic leukemia. *Data from Döhner,et al.1 †Other rare recurring translocations include AML with t(1;3)(p36.3;q21.3)/PRDM16::RPN1, AML (megakaryoblastic) with t(1;22)(p13.3;q13.1)/RB...
Based on the revised 4th edition of the WHO classification (WHO 2017), AML are classified into AML with recurrent genetic abnormalities, AML with myelodysplasia-related changes (AML-MRC) or AML, not otherwise specified (AML-NOS) [4]. Several changes are announced in the WHO 2022 [3] incorp...
Incidence, survival, and risk factors for adults with acute myeloid leukemia not otherwise specified and acute myeloid leukemia with recurrent genetic abnormalities: analysis of the surveillance, epidemiology, and end results (SEER) database, 2001–2013. Acta Haematol. 2018;139:115–27. Article Pub...
Other myelodysplasia-associated cytogenetic abnormalities seen in AML―MRC are uncommon when NPM1 is mutated and such rare cases should continue to be diagnosed as AML―MRC. NPM1 mutations are usually mutually exclusive of the other AMLs with r...