Human immunodeficiency virus type 1 (HIV-1)-specific broadly neutralizing monoclonal antibodies (bNAbs) have to date shown transient viral suppression when administered as monotherapy or as a cocktail of two antibodies1–4. A combination of three bNAbs p
The objective of the study was to examine the role of microsatellite instability (MSI) and BRAFV600Emutation in colorectal cancer (CRC) by categorising patients into more detailed subtypes based on tumour characteristics. Tumour samples from 762 populati
In the present invention, the term “homologous” refers to the degree of identity (see percent identity above) between sequences of two amino acid sequences, i.e. peptide or polypeptide sequences. The aforementioned “homology” is determined by comparing two sequences aligned under optimal cond...
HLA-A*01, HLA-A*02, and HLA-B*07 are examples of different MHC class I alleles that can be expressed from these loci. TABLE 5 Expression frequencies F of HLA-A*02 and HLA-A*24 and the most frequent HLA-DR serotypes. Frequencies are deduced from haplotype frequencies Gf within ...
In Table 1, the first SNP on each chromosome is the lead SNP from the first round of GWAS analysis, the rest are the additional SNP(s) detected on a chromosome. Sixteen SNPs on chromosome 14 have the same P-value in the first round, and these SNPs are in high LD with the two ...
The procedure of the exact tree method is described below. First, we made cross-tabs of genotypes between the groups of stroke patients and healthy controls. Then, we com- pared the prevalence of these alleles between the groups and calculated the P value of Fischer's exact test (See ''...
For the two polymorphisms of both ApoCIII and CETP genes, we estimated the coefficient of linkage disequilibrium D' (D/Dmax if D > 0) ± SD and P value for a two-marker combination using the 2LD program (Zhao et al. 2000). Since allelic frequencies of LPL mutations resulting in a ...
In a previous study (reference 6), the present inventors found that the alleles of a 5-HTT gene, a serotonin transporter gene, were associated with variation in antidepressant responses to SSRIs. In the present invention, the approach conducted in said previous study was extended to the allelic...
The terms “analog” herein in reference to .PDGF, KGF, IGF, and IGFBP protein refers to truncations, variants, alleles and derivatives thereof. Unless specifically mentioned otherwise, these terms encompass the bioactivities of “mature” KGF or “mature” PDGF “mature” IGF or “mature” IGFB...
and the predictive model achieved accuracies of 0.93, 0.87, and 0.84 using the internal and two external test sets, respectively. Additionally, CRISPR/Cas12a-based AIGS was constructed, and AIGS achieved 100% diagnostic accuracy in terms of IDH detection using both frozen tissue and FFPE samples...