We combined two different activating point mutations in the same gene and found that two of the resulting double mutants acquired unusual properties. These alleles, HOG1[sup D170A,F318L] and HOG1[sup D170A,F318S], induced a severe growth inhibition and had to be studied through an ...
7). Human NK cells express any combination of two CD16 alleles: the high affinity (ha) valine (V) allele or the lower affinity phenylalanine (F) allele [5]. Clinical studies have demonstrated that patients who are homozygous for the valine allele (V/V) have improved survival following ...
However, two different studies in mCRC patients with KRAS wild-type found a significant difference in outcomes among patients carrying different genotypes of this polymorphism18,25. We have evaluated this polymorphism in our cohort of KRAS mutated mCRC patients treated with cetuximab, similarly to ...
In the present invention, the term “homologous” refers to the degree of identity (see percent identity above) between sequences of two amino acid sequences, i.e. peptide or polypeptide sequences. The aforementioned “homology” is determined by comparing two sequences aligned under optimal cond...
The objective of the study was to examine the role of microsatellite instability (MSI) and BRAFV600Emutation in colorectal cancer (CRC) by categorising patients into more detailed subtypes based on tumour characteristics. Methods: Tumour samples from 762 population-based patients with sporadic CRC we...
FIG. 6 portrays the effects of combined treatment, with IFN-gamma (two different doses) and bispecific ligand-targeted and doxorubicin-packaged intact minicells, of human alveolar adenocarcinoma tumor xenografts established in 6 week-old female athymic nude mice with a tumor size of about 100 mm3...
Distributions of alleles, genotypes, and haplotypes at three loci defined by examined SNPs were not significantly different between the groups. However, the homozygote combination of 121 haplotype was more prevalent in the T2DM group than in the controls (17.9% vs 10.1%, P=0.039). No difference...
Human immunodeficiency virus type 1 (HIV-1)-specific broadly neutralizing monoclonal antibodies (bNAbs) have to date shown transient viral suppression when administered as monotherapy or as a cocktail of two antibodies1–4. A combination of three bNAbs p
1 for the predicted genomic offsets under different emission scenarios and decades (RCP4.5 2050, RCP8.5 2050, RCP4.5 2070 and RCP8.5 2070). Full size image Out of 50,000 randomly extracted SNPs, we identified 5446 and 7294 SNPs that were significantly associated with the top climatic ...
Interestingly, the combination of muCTLA-4Ig and anti-CD40L was most effective at prolonging xenograft rejection, and the hearts continued to function normally up to 22 days after the last huCTLA-4Ig treatment. The different outcome could reflect differences in affinity between muCTLA4-Ig and hu...