The discovery of drivers of cancer has traditionally focused on protein-coding genes1–4. Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Cancer Analysis of Whole Gen
sense strand是指编码链 不作为转录 的另一条DNA链为编码链,又称有意义链. antisense strand是指反义链 在基因的DNA双链中,转录时作为mRNA合成模板的那条 DNA单链叫做模板链或反义链. 还有的两个就不知道了. 分析总结。 antisensestrand是指反义链在基因的dna双链中转录时作为mrna合成模板的那条dna单链叫做...
ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models Nimrod Rotem, Iddo Magen, Ariel Ionescu, Noga Gershoni-Emek, Topaz Altman, Christopher J. Costa, Tal Gradus, Metsada Pasmanik-Chor, Dianna E. Willis, Iddo Z. Ben-Dov, Eran Horn...
Double-strand break (DSB)In vitro transcriptionPlasmid DNADNA damage response (DDR) is essential for the maintenance of genomic integrity. We have recently discovered the generation of noncoding RNA from a DNA double-strand break (DSB) in an MRE11-RAD50-NBS1 complex-dependent manner, which ...
potassium voltage-gated channel, KQT-like subfamily, member 1 opposite strand 1 LC3B-II/MAP1LC3B microtubule-associated protein 1 light chain 3 beta-II LincRNA long intervening noncoding RNA LINCMD1 long noncoding RNA, muscle differentiation MALAT1 metastasis associated lung adenocarcinoma transcript ...
Innovations in high-throughout sequencing approaches are being marshaled to both reveal the composition of the abundant and heterogeneous noncoding RNAs th
Night-break (NB) has been proven to repress flowering of short-day plants (SDPs). Long-noncoding RNAs (lncRNAs) play key roles in plant flowering. However, investigation of the relationship between lncRNAs and NB responses is still limited, especially in
Nonetheless, most attention to the participation of noncoding RNAs in PRRSV-host interactions has been focused on small noncoding RNAs such as microRNAs [6]. Only two studies [29,30] have aimed their attention at lncRNAs, resulting in the fact that the majority of these possibly relevant ...
Long noncoding RNAs (lncRNAs) are linked to cancer via pathogenic changes in their expression levels. Yet, it remains unclear whether lncRNAs can also impact tumour cell fitness via function-altering somatic “driver” mutations. To search for such drive
can target the coding strand of SARS-CoV-2, and lately inhibit its replication.89,90In addition, some regulatory networks are controlled by the circRNA/lncRNA-miRNA-mRNA regulatory axis in the infected cells. Relevant research has reorganized a quintuple regulatory network including one miRNA (miR...