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Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are unk
Long non-coding RNAs (lncRNAs) play vital roles in the pathogenesis of infectious diseases, but the role of lncRNAs in herpes simplex virus 1 (HSV-1) infection remains unknown. Using RNA sequencing analysis, we explored lncRNAs that were highly expressed in murine retinal photoreceptor cell-derive...
In most cases, we sequenced directly the ends of BAC clone inserts by following the protocols for template preparation provided by The Institute for Genome Research (TIGR) and for Big Dye terminator cycle sequencing as recommended by PE Applied Biosystems. Ordering of smaller contigs relative to ...
The switch from transcription to genome replication takes place when sufficient amounts of viral protein have accumulated. The polymerase complex is responsible for the synthesis of full-length plus-strand antigenomic RNA, which in turn serves as the template for synthesis of minus-strand genomic RNA...
Carex L., a grass genus commonly known as sedges, is distributed worldwide and contributes constructively to turf management, forage production, and ecological conservation. The development of next-generation sequencing (NGS) technologies has considerabl
Introns, noncoding sequences interrupting protein-coding genes, are the hallmark of eukaryotic gene organization (23). However, the role of intron in AMP gene regulation was previously not known. This is the first study demonstrating the regulatory role of an intron in an AMP gene and associatio...
Keywords: non-coding RNA; lncRNA; virus; gammaherpesvirus; MHV68 1. Introduction For years, our understanding and interpretation of mammalian genomes was almost exclusively focused on the 1% of the genome that is protein-coding. However, over the last 15 years, it has Non-coding RNA 2019, ...
Preeclampsia (PE) is one of the pregnancy complications, leading to major maternal and fetal morbidity and mortality; however, the underlying mechanisms of PE still remain unclear. We aimed to explore the role of apolipoprotein A1 (APOA1) in the pathophy
The format can be explained by sections, and we use annotation for GENE1 as an example: GENE1 : gene name CODING_GENE : transcript name +: forward strand Nonsynonymous, Normal_Splice_Site, Exon : various annotation types CCT/Pro/P->CAT/His/H : Proline to Histidine mutation ...