In addition to its role in classic promoter-driven transcription of coding RNA, it is now clear that RNA also drives abundant expression of noncoding RNA. For the majority of this the functional significance remains unclear. Moreover, its regulation and impact are hard to predict because it ...
48). Although the mechanism of transcription initiation and termination can be different from those of mRNAs,49most lncRNAs are transcribed by Pol II. Nevertheless, examples exist of lncRNAs transcribed by Pol I
transcriptionrepertoireprocessesmoleculespromotersNon-coding RNAs have been found to regulate many cellular processes and thus expand the functional genetic repertoire contained within the genome. With the recent advent of genomic tools, it is now evident that these RNA molecules play central regulatory ...
These large-scale changes in nuclear architecture were associated with the deposition of activating epigenetic marks across the loop domain, plausibly facilitating phase separation. These data indicate how, during developmental progression and tumor suppression, non-coding transcription orchestrates chromatin ...
ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models Nimrod Rotem, Iddo Magen, Ariel Ionescu, Noga Gershoni-Emek, Topaz Altman, Christopher J. Costa, Tal Gradus, Metsada Pasmanik-Chor, Dianna E. Willis, Iddo Z. Ben-Dov, Eran Horn...
(Fig. 1F). The upregulated KEGG pathways include “MAPK signaling pathway”, “PI3K-Akt signaling pathway”, “pathways in cancer” et al. (not shown). These findings are consistent with growth arrest and reduced growth factor signaling in starved cells, as well as decreased gene transcription...
In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing a particularly promising avenue of investigation. The identification of ncRNA-encoded peptides in human ca
重叠和双向转录(Overlapping and bidirectional transcription )在真核生物中是一种丰富而保守的现象[154,218]。然而,在哺乳动物中,将感觉反义配对转录本加工成siRNA及其功能相关性仍存在争议,需要实验证据,尤其是在单细胞水平上。LncRNA加工成小RNA分子可能依赖于不同的细胞机制,如RNase Pand RNase z介导的MALAT1小细...
The observation that many, if not all, functional enhancers generate non-coding enhancer RNAs (eRNAs) has raised critical questions regarding the potential biological roles of the enhancer transcription process and, indeed, of eRNAs. This article reviews
-temporal specificities. Our analysis uncovered that the BETL at 12 DAP undergoes the most dynamic transcriptional regulation for both coding and long noncoding transcripts. In addition, our transcriptome analysis revealed spatio-temporal regulatory networks of transcription factors, imprinted genes, and...