In the United States, cocaine is a Schedule II drug that is used entirely differently. Most users inhale the drug by “snorting” it, taking it orally, or injecting it. The rock form of cocaine is often referred to as crack or crack cocaine, and is smoked. Regardless of the form, ...
FR schedules to a more efficient procedure with cocaine or fentanyl vs. food. Furthermore, the FR schedule of food delivery was manipulated to determine whether increased drug choice under a VR (compared with a FR) schedule depends on the size of the schedule of nondrug reinforcement. Methods...
cocaine on a fixed ratio 1 schedule for 5 days. Subjects then received bilateral, intra-basolateral amygdala complex infusions of a dopamine D1 receptor antagonist (SCH23390, 0.25–2.0μg/side; experiment 1), a dopamine D2 receptor antagonist (raclopride, 0.625–5.0μg/side; experiment 2),...
Additional penalties may apply if the possession of cocaine with intent to sell it took place on or close to a school, homeless shelter, or drug treatment facility. Likewise, a conviction for possessing or purchasing cocaine base for sale, if the amount of cocaine base exceeds 1 kilogram (2.2...
Response-outcome contingency degradation was accomplished simi- larly to our prior reports.18–22 In the 25 min 'non-degraded' session, one nose-poke aperture was occluded, and responding on the other aperture was reinforced using a fixed ratio 1 schedule. In the 25 min 'degraded' session, ...
All rats were trained to press an active lever for cocaine reward (i.v. infusion of cocaine hydrochloride) for at least 10 days on a fixed ratio 1 (FR1) schedule of reinforcement in 2 h sessions to reach a criterion of 410 cocaine infusions/day (0.2 mg/50 μl infusion for males, ...
Topical Solution: Schedule II 4% (40 mg/mL) 10% (100 mg/mL) Intranasal Solution: Schedule II 4% (Goprelto, Numbrino) NasalCavityAnesthesia Numbrino or Goprelto Indicated for induction of local anesthesia of the mucous membranes when performing diagnostic procedures and surgeries on or through...
Tang M, Falk JL (1987) Oral self-administration of cocaine: chronic excessive intake by schedule induction. Pharmacol Biochem Behav 28:517–519 Article PubMed CAS Google Scholar Tennant FS, Sagherian AA (1987) Double-blind comparison of amantadine and bromocriptine for ambulatory withdrawal from ...
GOPRELTO contains cocaine, a Schedule II controlled substance. Abuse GOPRELTO contains cocaine, a substance with a high potential for abuse. GOPRELTO can be misused and abused, which can lead to addiction. GOPRELTO may also be diverted for abuse purposes [seeWARNINGS AND PRECAUTIONS]. ...
We used in vivo fast scan cyclic voltammetry to test the effects of hypocretin antagonists on dopamine signaling in the nucleus accumbens core and a progressive ratio schedule to examine the effects of these antagonists on cocaine self-administration. Results demonstrate that blockade of either ...