Today, cocaine is a Schedule II drug, meaning that it has highpotential for abuse but can be administered by a doctor for legitimate medical uses, such as local anesthesia for some eye, ear, and throat surgeries. There are basically two chemical forms of cocaine: the hydrochloride sal...
All rats were trained to press an active lever for cocaine reward (i.v. infusion of cocaine hydrochloride) for at least 10 days on a fixed ratio 1 (FR1) schedule of reinforcement in 2 h sessions to reach a criterion of 410 cocaine infusions/day (0.2 mg/50 μl infusion for males, ...
A decrease in the number of cocaine infusions performed by rats was obtained under the fixed ratio-1 schedule of reinforcement as well as under a progressive ratio schedule, which evaluates the motivation of the animals for the drug. Decrease in cocaine self-administration was accompanied with ...
Rats were trained to lever-press for cocaine (1.0 mg/kg/infusion) under a fixed ratio 1 schedule of reinforcement for 10 days. After training, the rats received a bilateral microinjection of an α1 noradrenergic antagonist (terazosin: 1.0, 5.0, or 10 mM/side), a D1 dopaminergic ...
A 2023 study suggested that ketamine may be an effective treatment for cocaine-use disorders, with the researchers revealing that ketamine was associated with significant improvements in remission among people with cocaine-use disorders. How can I try ketamine? As mentioned, ketamine is a Schedule 3...
3.1. Cocaine self-administration Male and female rats were trained on a seeking-taking chained schedule of self-administration for IV cocaine (2 h per day) and then exposed to four days of punishment testing (Fig. 1). Rats were trained on either an RR20 or RI60 schedule for the seeking...
The catechol-o-methyltransferase (COMT) genetic variations produce pleiotropic behavioral/neuroanatomical effects. Some of these effects may vary among sexes. However, the developmental trajectories of COMT-by-sex interactions are unclear. Here we found
The results showed that prior yoked exposure to cocaine reduced subsequent drug-taking behavior on a progressive-ratio but not on a fixed-ratio schedule. Finally, Experiment 3 used a choice test to determine the impact of yoked drug delivery on the relative preference for cocaine versus water....
Male Sprague-Dawley rats (n=6) were trained to self-administer MDPV under a progressive ratio schedule of reinforcement, and maintained under this schedule with daily access to 0.32 mg/kg/inf cocaine or 0.032 mg/kg/inf MDPV. Dose-response curves for the effects of lorcaserin on cocaine and ...
Rats were trained to self-administer cocaine on a fixed-ratio 5 schedule of reinforcement with a 1-min time-out period following each infusion. Cocaine was available at doses of either 0.1, 0.3 or 1.0 mg/kg/infusion. A low dose (3 渭g/kg) of the D1 antagonist SCH23390 caused an ...