Tissue factor (TF) is a cellular receptor for coagulation factor VII (FVII), and its activated form, factor VIIa (FVIIa). Exposure of TF to blood upon vascular injury leads to TF-FVIIa complex formation, which triggers blood coagulation cascade. In health, TF is constitutively expressed in...
Tissue factor (TF) is a cellular receptor for coagulation factor VII (FVII), and its activated form, factor VIIa (FVIIa). Exposure of TF to blood upon vascular injury leads to TF-FVIIa complex formation, which triggers blood coagulation cascade. In health, TF is constitutively expressed in...
Factor VII(a) is responsible for triggering the clotting cascade that eventually leads to thrombin generation, fibrin deposition, and platelet activation. Factor VIIa (FVIIa) is enzymatically active only after complex formation with its cellular receptor, tissue factor (TF). Factor VIIa–TF activity...
Tissue factor (TF), the trigger for coagulation, is normally restricted from contact with the circulation by being expressed largely in adventitial fibroblasts. Once the vessel is compromised, the exposed TF binds escaping factor VIIa (fVIIa) molecules with high affinity to form a potent ...
Related to Coagulation cascade:Coagulation factors co·ag·u·late (kō-ăg′yə-lāt′) v.co·ag·u·lat·ed,co·ag·u·lat·ing,co·ag·u·lates v.tr. To cause transformation of (a liquid or sol, for example) into or as if into a soft, semisolid, or solid mass. ...
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1.1 Overview of the Coagulation Cascade The coagulation cascade is composed of two pathways; the intrinsic, or contact activation pathway and the extrinsic, or tissue factor pathway (Fig. 1.1). The main function of the coagulation cascade is the formation of an insoluble fibrin clot...
COAGULATION CASCADE | Overview P. Neuenschwander 被引量: 0发表: 2006年 Role of Tissue Factor in Venous Thrombosis Tissue factor (TF) is the primary initiator of the coagulation cascade and is essential for hemostasis. Under pathological conditions, TF is released into ... DA Manly,J Boles,N ...
Patients with chronic kidney disease (CKD) commonly exhibit hypercoagulability. Increased levels of uremic toxins cause thrombogenicity by increasing tissue factor (TF) expression and activating the extrinsic coagulation cascade. TF is induced in monocyt
To clarify factors that may contribute to the development of intratumoral hemorrhage, we analyzed the expression of tissue factor (TF), an initiator of the extrinsic coagulation pathway, and of tissue factor pathway inhibitor (TFPI) in glioblastomas with or without massive intratumoral hematoma. Among...