In the Northeast region of Brazil, the species Bothrops erythromelas and Bothrops leucurus are the main responsible for snakebite accidents. Due to the specific action of Bothrops venoms on several components of the coagulation cascade, the objective of this work was to characterize the coagulotoxic...
ECs, together with pericytes and ECM proteins, can regulate blood flow, the coagulation cascade, fluid and solute exchange, and leukocyte trafficking. While capillary and venular functions in inflammation are well characterized, the arteriolar contribution to inflammation has only recently come into ...
Interaction of the main pathways involved in adhesion formation. Inflammation, which is mainly mediated by macrophages, through cytokines and growth factors initiates the healing process by promoting fibrin exudate formation. Coagulation is simultaneously elicited, resulting in the formation of fibrin clots,...
Despite one of the main feature of cachexia being anorexia, the mode of tissue wasting is completely different from the one induced by starvation.9Of note, treating anorexia through parenteral nutrition does not reverse cachexia, indicating that the decreased calories intake is not the primary cause...
Circulating monocytes, MPs, and activated endothelium produce a procoagulant protein, TF, under pathological conditions39,40. These intravascular sources of TF may trigger the formation of venous clots via the extrinsic pathway of the blood coagulation cascade. Although activated monocytes and tumor cells...
These intravascular sources of TF may trigger the formation of venous clots via the extrinsic pathway of the blood coagulation cascade. Although activated monocytes and tumor cells are the primary sources of TF-positive MPs in the circulation[41], TF has been identified on leukocyte MPs, ...
[47] Mutations were found in NF-κB pathway members, highlighting the recognized importance of dysregulation of this pathway in myeloma, but also in genes involved in protein modification, histone methylation and blood coagulation, suggesting novel oncogenic mechanisms in myeloma. A number of groups ...
preventing coagulation. The dispersed droplets mix with a larger volume o clean, dry air, which evaporates any volatile portion o the droplets. The VOAG generates primary droplets in the 21 to 48 micrometer range using a standard, interchangeable set o 10 and 20 micrometer ...
This can result in renal epithelial cell apoptosis, changes in plasma creatinine levels, and alterations in vasoactive mediators, coagulation, and fibrinolysis, alongside factors like vascular endothelial growth factor [50,51,52]. The RAAS, activated by mechanical ventilation, plays a crucial role in...
It is recognised that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could induce a dramatic pro-inflammatory cascade, dominated mostly by IL-1, IL-6 and IFN-γ [46]; although AOSD and COVID-19 have different pathogen- esis, the hyperinflammation provoked by this ...