Coagulation factor XIII (FXIII) is a plasma circulating heterotetrameric pro-γ-transglutaminase, which plays an important role in the terminal phase of the clotting cascade by covalently cross-linking the pre-formed fibrin clot into an insoluble one, thereby protecting it from premature fibrinolysis...
Factor VII(a) is responsible for triggering the clotting cascade that eventually leads to thrombin generation, fibrin deposition, and platelet activation. Factor VIIa (FVIIa) is enzymatically active only after complex formation with its cellular receptor, tissue factor (TF). Factor VIIa–TF activity...
Related to coagulation inhibitors: Coagulation cascade, Lupus coagulation inhibitorco·ag·u·late (kō-ăg′yə-lāt′) v. co·ag·u·lat·ed, co·ag·u·lat·ing, co·ag·u·lates v.tr. To cause transformation of (a liquid or sol, for example) into or as if into a soft, ...
3.Obs.coagulated. [1350–1400; Middle English: solidified < Latincoāgulātus,past participle ofcoāgulāreto curdle, derivative ofcoāgulum;seecoagulum,-ate1] co•ag`u•la′tion,n. co•ag′u•la`tor,n. co•ag′u•la•to`ry(-ləˌtɔr i, -ˌtoʊr i)co•ag′...
Damage to the vessel wall exposes Coagulation Factor III to circulating Factor VII, triggering the proteolytic cascade that results in fibrin clot formation. Coagulation Factor III plays an important role in thrombotic diseases, disseminated intravascular coagulation, and atherosclerosis. It also plays a...
Damage to the vessel wall exposes Coagulation Factor III to circulating Factor VII, triggering the proteolytic cascade that results in fibrin clot formation. Coagulation Factor III plays an important role in thrombotic diseases, disseminated intravascular coagulation, and atherosclerosis. It also plays ...
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Antithrombin, formerly referred to as antithrombin III, is a heparin-binding protein and the major plasma inhibitor of coagulation proteases, primarily thrombin and factor Xa. In addition to its function in controlling the process of coagulation, antithrombin has potent anti-inflammatory properties. This...
Tissue factor (TF) is a cellular receptor for coagulation factor VII (FVII), and its activated form, factor VIIa (FVIIa). Exposure of TF to blood upon vascular injury leads to TF-FVIIa complex formation, which triggers blood coagulation cascade. In health, TF is constitutively expressed in...
Factor VII(a) is responsible for triggering the clotting cascade that eventually leads to thrombin generation, fibrin deposition, and platelet activation. Factor VIIa (FVIIa) is enzymatically active only after complex formation with its cellular receptor, tissue factor (TF). Factor VIIa–TF activity...