neuronsneuro-inflammationoxidative stressMicroglia, the resident immune cells of the brain, have been implicated in numerous neurodegenerative and neurodevelopmental diseases. Activation of microglia by a variety of stimuli induces the release of factors, including pro- and anti-inflammatory cytokines and ...
Viviani B. Preparation and coculture of neurons and glial cells. Curr Protoc Cell Biol. 2006; Chapter 2 (Unit 2):7. [ PubMed ]Viviani B (2006) Preparation and coculture of neurons and glial cells. Curr Protoc Cell Biol Chap. 2:Unit 2.7. : 10.1002/0471143030.cb0207s32...
ofNSCsastrogMainaremeanenu’regulateinnateimmunityandparticipateinadaptiveimmuneresponses.Microgliaarenotonlyscavengercellsthatinterveneduringneuroinflammatoryorneuroinfectiousdisorders,butalsoexertcrucialphysiologicalfunctionsinthedevelopingandadultCNS.suchastheinductionofapoptosisinspecificsubpopulationsofdevelopingneurons,。’...
Figure 1. Schematic model of the glioma tumor microenvironment (TME). The cellular components of the glioma microenvironment include glioma cells and glioma stem cells (GSCs), endothelial cells, pericytes, microglia, macrophages, T cells, neurons, and astrocytes. The figure was created using BioRende...
However, the differentiation process and growth conditions of hiPSC-derived neurons are non-trivial. In order to study neuronal network formation and (mal)function in a fully humanized system, we have established an in vitro co-culture model of hiPSC-derived cortical neurons and human primary ...
Astrocyte-Microglia Cooperation in the Expression of a Pro-Inflammatory Phenotype Glial cells not only serve supportive and nutritive roles for neurons, but also respond to protracted stress and insults by up-regulating inflammatory proc... Barbierato,Massimo,Facci,... - 《Cns & Neurological Disorder...
Neurogenesis (the birth of new neurons) continues postnatally and into adulthood in the brains of many animal species, including humans. This is particular... Jacobs,L B.,van,... - 《Molecular Psychiatry》 被引量: 955发表: 2000年 CCL2 is a key mediator of microglia activation in neuropath...
rat's acellular spinal cord scaffold and co-culture with rat's spinal cord neuron in vitro D-X Ban, Y Liu, T-W Cao, S-j Gao and S-Q Feng Study design: The rat's acellular spinal cord scaffold (ASCS) and spinal cord neurons were prepared in vitro to explore their biocompatibility....
Li-Jiuan ShenSchool of PharmacyJournal of Neuroscience ResearchYu HH, Wu FL, Lin SE, Shen LJ: Recombinant arginine deiminase reduces inducible nitric oxide synthase iNOS-mediated neurotoxicity in a coculture of neurons and microglia. J Neurosci Res 2008, 86:2963-2972....
The researchers showed that optimizing the device’s geometric characteristics and cell culture parameters can enhance the attachment and growth of neuron-like human cells (SH-SY5Y cells), regulate the migration of neurons and Schwann cells between compartments, and facilitate prolonged studies on cell...