8 例DLBCL患者在初次诊断时进行了NGS检测,10例患者在复发时进行NGS检测,其中2例患者在初次诊断和复发时均进行了NGS检测。从CNS复发开始计算的中位随访时间为8.55个月,所有患者均进行了疗效评估,其中71.4 %的DLBCL患者获得缓解。研究中共有11例DLBC...
Central nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL) is associated with a poor prognosis, with a median overall survival of approximately five months []. The risk for CNS disease has been estimated to be about 5% overall [], but it is significantly higher in ...
Re AlessandroCavallo FedericaMusuraca GerardoBlood Cancer JournalAyed AO, Chiappella A, Pederson L, Laplant BR, Congiu AG, Gaidano G, et al. CNS relapse in patients with DLBCL treated with lenalidomide plus R-CHOP (R2CHOP): analysis from two phase 2 studies. Blood Cancer J. 2018 Jun 26...
brain,encephalon- that part of the central nervous system that includes all the higher nervous centers; enclosed within the skull; continuous with the spinal cord substantia alba,white matter- whitish nervous tissue of the CNS consisting of neurons and their myelin sheaths ...
- 《Journal of Clinical Oncology》 被引量: 8发表: 2016年 Osteolytic lesions in patients with relapse of diffuse large B-cell lymphoma treated with lenalidomide Dear Editor, The outcome of patients with diffuse large B-cell lymphoma ( DLBCL ) experiencing relapse after stem cell transplantation ...
总的来说,HGBCL-DH-BCL2的CNS复发风险低于先前报道,而DZsig可细化GCB-DLBCL的风险分层。 参考文献 1.Alduaij W et al.CNS Relapse in High-Grade B-cell Lymphoma with MYC and BCL2 Rearrangements and Dark-Zone Signature Expressing DLBCL.Blood . 2024 Oct 23:blood.2024025725. doi: 10.1182/blood.202...
Although overall survival in diffuse large B cell lymphomas (DLBCL) has improved, central nervous system (CNS) relapse is still a fatal complication of DLBCL. For this reason, CNS prophylaxis is recommended for patients at high risk of CNS disease. However, no consensus exists on definition of...
"With such low rates of CNS relapse (even among patients classically considered at high risk) and no evidence of a survival benefit, the numbers needed to treat to prevent death from CNS relapse would be quite high based on our findings," they point out. ...
First-line therapy in PCNSL usually comprises high-dose methotrexate in combination with additional agents, but the optimal treatment regimen, especially in relapse, remains subject of ongoing studies [2]. Scarce biomaterial is available for scientific purposes because the diagnostic gold standard in ...
Impact of central nervous system (CNS) prophylaxis on the incidence of CNS relapse in patients with high-risk diffuse large B cell/follicular grade 3B lymp... outcome of 95 high-risk DLBCL/FL grade 3B patients treated with R-CHOP or its derivatives with (N = 57) or without (N = 38)...