利妥昔单抗联合环磷酰胺、阿霉素、长春新碱和泼尼松(R-CHOP)方案是DLBCL的标准一线治疗方案,但对于病灶累及中枢神经系统(CNS)、EB病毒(EBV)阳性或双打击等特殊DLBCL亚型而言,R-CHOP方案疗效欠佳,这部分患者易陷入疾病复发/难治困境,且预...
参考文献: 1.Bobillo S,et al. Promising activity of selinexor in the treatment of a patient with refractory diffuse large B-cell lymphoma and central nervous system involvement. Haematologica. 2018 Feb;103(2):e92-e93. d...
In case a patient comes in with adrenal gland involvement, kidney involvement, or breast involvement, obviously I don’t really look at the CNS-IPI. Those are really high-risk patients who need serious prophylaxis. As far as the mode, there’s a lot of to and from between using ...
According to the standard IPI, the cumulative incidences of CNS involvement at 2 years were 1.3, 4.6, 8.8, and 12.7% in the low-, low-intermediate-, high-intermediate-, and high-risk groups, respectively (p <.001). This result is comparable with that of the CNS-IPI. Patients with ...
[For those with triple-hit and double-hit lymphoma], it was similar. All of those patients…were allowed in the study, which [led to] a much great benefit to the study. It also allowed for patients with CNS involvement; often we exclude them. This was very encouraging, and these respon...
groups. Those in the lower risk group had a 0.6% 2-year incidence of CNS relapse, whereas the highest risk group had a greater than 10% chance. However, the CNS-IPI does not adequately capture all patients at high risk of CNS relapse, particularly those with testicular involvement, who of...
Bone marrow biopsy: involvement with DLBCL Conclusion: stage IV DLBCL, non-GCB subtype IPI score high-risk; CNS relapse score intermediate risk Treatment Treated with R-CHOP for 6 cycles End-of-treatment PET/CT demonstrates a Deauville 2 complete remission ...
It is important to note however that the blood–brain barrier advanced stage, extranodal disease, elevated lactate dehydrogenase (LDH), and renal/adrenal involvement3,8. The CNS-International Prognostic Index (CNS-IPI) is a validated scoring system3 that risk-stratifies patients with (BBB) ...
"Both patients with CNS involvement by lymphoma who were treated on study had complete resolution of their CNS disease," said Abramson. "One patient with progression after CR re-expanded CAR T cells following incisional biopsy and achieved a second CR without intervening therapy." In the core ...
Antitumor activity and safety of zanubrutinib combined with R-CHOP regimen in the treatment of newly diagnosed non-GCB DLBCL with extranodal involvement: a prospective phase II study. 泽布替尼联合R-CHOP治疗新诊断结外受累...