此外,在2012年的样品中未发现2012年样品中检测到的13q缺失异常这一事实增加了以下可能性:这些是最早可追溯至2012年的肿瘤细胞的不同亚群。 在2016年和2019年进行的两次NGS测试也获得了与众不同的结果,这引发了一个疑问,即DLBCL是否...
此外,在2012年的样品中未发现2012年样品中检测到的13q缺失异常这一事实增加了以下可能性:这些是最早可追溯至2012年的肿瘤细胞的不同亚群。 在2016年和2019年进行的两次NGS测试也获得了与众不同的结果,这引发了一个疑问,即DLBCL是否实际上代表了新生肿瘤。该XPO1 p.E571K突变是在两个测试中始终检测到的唯一变量...
研究背景 Richter转化(RT)通常是指慢性CLL患者转化为侵袭性淋巴瘤,大多数情况下是转化为弥漫大 B 细胞淋巴瘤(DLBCL)或霍奇金淋巴瘤(HL)。接受R-CHOP等化学免疫疗法治疗的RT患者预后较差,需要更有效的靶向治疗。然而,在这一领域的...
type of lymphoma, accounting for 25% to 30% of NHLs.5 The focus in recent years has shifted toward the identification of molecular alterations and specific pathogenetic pathways leading to transformation in DLBCL.Gene expression profiling(GEP) of DLBCLs has identified at least two major molecular...
Histologically aggressive CLL: confluent or very large proliferation center or > 40% Ki67 index; not the equivalent of Richter transformation (Blood 2018;131:2761) Richter transformation: usually high grade B cell lymphoma (DLBCL) appearing in the context of CLL; confluent areas of large cells are...
The treatment of chronic lymphocytic leukemia (CLL) is poised to undergo a dramatic transformation as multiple new agents begin to gain approval in the relapsed/refractory setting. The question that remains unanswered is how these agents will be sequenced. As of now, John C. Byrd, MD, believes...
characterized by a high degree of complexity due to the presence of three sequentially occurring neoplastic clones, the application of modern and sensitive molecular technologies uncovered that DLBCL-RS, initially considered as a de novo lymphoma, was instead the result of the transformation of a pre...
该病灶表现为H3K27me3缺失,极局灶性S100阳性。MDM2扩增、DOG1、KIT均为阴性。 MPNST伴横纹肌母细胞分化。 53-已知CLL/SLL患者的LN。你会怎么签发? Richter transformation? The immunostains is Ki67 P53 它们不是DLBCL的大细胞。 诊断:Accelerated CLL/SLL。
such as dose reduction or supportive care. More importantly, we're not seeing signals that the biology of the disease is changing in terms of transformation to more high-risk histology, as we’ve seen with other malignancies. I think it's important to continue to have follow-up studies from...
慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(chronic lymphocytic leukemia/small lymphocytic lymphoma,CLL/SLL)是一种低度恶性的B细胞肿瘤,约有2%~9%的患者会进展为侵袭性淋巴瘤,其中最常见的是弥漫大B细胞淋巴瘤Richter转化(diffuse large ...