The nucleotide sequence of the genes encoding this novel beta-lactamase was found to be >94% identical to the nucleotide sequences of the plasmid-mediated AmpC-type beta-lactamases originating from Citrobacter freundii. This enzyme differed from CMY-2 by 3 amino acid substitutions and was ...
Ceftriaxone resistance was due to the production of the CMY-2 AmpC beta-lactamase by seven isolates and the CTX-M-14 beta-lactamase by the remaining isolate. Both beta-lactamase genes were carried on conjugative plasmids. In a 2.5-kb region encompassing the bla(CMY-2) gene, at nucleotide ...
A NTIMICROBIAL A GENTS AND C HEMOTHERAPY , Jan. 1996, p. 221–224 Vol. 40, No. 10066-4804/96/$04.0010Copyright q 1996, American Society for MicrobiologyCharacterization of the Plasmidic b-Lactamase CMY-2,Which Is Responsible for Cephamycin ResistanceA. BAUERNFEIND, 1 * I. STEMPLINGER, 1...
Cross resistance to cefiderocol and ceftazidime-avibactam in KPC beta-lactamase mutants and inoculum effect Objectives: Ceftazidime-avibactam and cefiderocol are recently commercialized molecules active against highly drug-resistant bacteria, including carbapenem... CA Hobson,A Cointe,H Jacquier,... - ...
AmpC BER is an extended substrate spectrum class C β-lactamase with a two-amino-acid insertion in the R2 loop compared with AmpC EC2. The crystal structures of AmpC BER (S64A mutant) and AmpC EC2 were determined. Structural comparison of the two proteins revealed that the insertion increa...
beta-lactamase CMY-2 beta-lactamase CMY-2(beta-lactamase CMY-2) CAS: 化学式: 中文名beta-lactamase CMY-2 英文名beta-lactamase CMY-2 英文别名beta-lactamase CMY-2
This study was performed to characterize two E. coli isolates collected in two different Portuguese hospitals, both carrying a novel CMY-2-type 尾-lactamase-encoding gene. Findings:Both isolates, INSRA1169 and INSRA3413, and their respective transformants, were non-susceptible to amoxicillin, ...
-lactamase such as Klebsiella spp. or Escherichia coli. This study was performed to characterize two E. coli isolates collected in two different Portuguese hospitals, both carrying a novel CMY-2-type ??-lactamase-encoding gene. Findings Both isolates, INSRA1169 and INSRA3413, and their ...
2001. Inactivation of CMY-2 beta-lactamase by tazobactam: initial mass spectroscopic characterization. Biochim. Biophys. Acta 1547:196-205.Bonomo RA, Liu J, Chen Y, Ng L, Hujer AM, Anderson VE. 2001. Inactivation of CMY-2 β-lactamase by tazobactam: initial mass spectroscopic characterization ...
coli. The ESBL/pAmpC type beta-lactamases were as follows: CMY-2 (n=46), CMY-2+TEM-1b (n=63), SHV-12 (n=5), SHV-12+TEM-1b (n=12), CTX-M-3 (n=14), CTX-M-3+TEM-1b (n=1), CTX-M-15 (n=4), CTX-M-15+TEM-1b (n=4), and CTX-M-1 (n=3). Moreover, ...