CMV pp65 specific cytotoxicity was in the normal range by 4 weeks post-infusion. Unfortunately our patient was diagnosed with recurrent leukemia at 3 weeks post-infusion, precluding long-term follow-up of his immune status. Considering the fact that this patient did not receive any other ...
Viral load, gender, and sample age were not found to be associated with any particular UL146 genotype. Conclusions: No particular UL146 genotype was associated with cCMV in this nationwide retrospective case- control study. Associations between CMV disease and disrupted or polymorph CMV genes among...
Although, HCMV infection is mostly asymptomatic due to host anti-viral immunity, it may lead to oncogenic transformation of normal cells and cancer, when host is immunocompromised owing to immunosuppressive drugs or infection with HIV. Numerous studies have shown that type I interferons (I-IFNs) ...
This patient presented extreme sensitivity to varicella-zoster virus, HCMV and herpes simplex I infections, despite normal antibody and T cell functions. In addition, low NK cell cytotoxic activity correlates with increased sensitivity to HCMV disseminated disease [21] while increased NK cell activity...
The Betaherpesviridae human cytomegalovirus (HCMV) is know to cause, in the immunocompetent host, an infection that usually range from asymptomatic to mild. Serious complications can however be the result of the infection of immunocompromised hosts6. In opposition to laboratory strains of HCMV, whi...
In the non-intervention group the physician arbitrarily decides on the application rate of the immunosuppressive medication within the defined normal target range of trough levels, whereas in the intervention group the immunosuppressive medication is additionally steered by measurement of Tvis levels. ...
(64%) were receiving steroid treatment; Cytotect®CP was used as monotherapy (n = 7) and in combination (n = 16). Overall, response was observed in 18 patients (78%) with a median time of 15 days (range: 3–51). Of the 18 responders, 4 experienced CMV reactivation, ...
CT Brain and CSF studies were normal. APLA was negative. A diagnosis of SLE was confirmed and treatment initiated with glucocorticoids, hydroxychloroquine, and azathioprine. Chorea resolved and never recurred. Conclusion: Chorea is a well-recognized but infrequent manifestation of SLE. Rarely, it ...
Further, using MHC-peptide multimers we have been able to demonstrate the simultaneous presence of CD8+ve cells recognizing peptide epitopes from CMV pp65 (range 2.32–21%) and Adenovirus hexon (1.07–8.08%) in the CTL cultures. So far we have treated 6 patients in this phase I CMV ...
HCMV viral load, it was observed that renal rejected patients during early infection stages had a significantly higher viral load (7.84 + 0.89 DNA log copies) compared to non-rejected patients (6.34 + 1.08 DNA log copies) (p-value 0.007). Similarly, in late rejection cases, the viral log...