(2014). Variation analysis of six HCV viral load assays using low viremic HCV samples in the range of the clinical decision points for HCV protease inhibitors. Med Microbiol Immunol. 204, 515- 525.Wiesmann F, Naeth G, Sarrazin C, Berger A, Kaiser R, Ehret R, et al. Variation analysis...
Among patients the male and female representation was equal as shown in Table1. Mean age of non-SVR group was 51 years (range 34–63 years), higher than the SVR group (mean age 43 years, range 21–62). The two groups were compared and statistically significant difference was observed in...
Median ALT and HCV RNA levels at the time of HCV detection were 145 IU/L [inter-quartile range (IQR): 73 – 385] and 73,760 IU/ml (IQR: 3,269 - 805,345), respectively. Seventy-five percent (n = 33) of individuals with HIV co-infection were on antiretroviral therapy at the ...
HCV RNA level, median (range), log10IU/ml 6.2 (0.7–7.6) 6.2 (2.5–7.8) Baseline HCV RNA level, IU/ml, n (%) <1 × 106 392 (41) 446 (41) ≥1 × 106 573 (59) 630 (59) <6 × 106 734 (76) 850 (79) ≥6 × 106 231 (24) 226 (21) Fibrosis stage...
HCV fusion depends on E1 and E2, viral dose, and occurs within a specific pH range. Targeting pH dependent endocytosis is a useful tool to identify antiviral drugs against. A major advancement to look into HCV entry process was the development of HCVpp, consisting of native HCV envelope ...
Viral load decrease in responder and treatment-failing patients was compared at the baseline, 1, 2, 4 and 8 weeks, and after stopping with the using Abbott HCV-RNA assay (Abbott Park, Illinois, U.S.A.). Viral RNA was extracted from serum samples using the automatic Easy Mag extractor (...
HCV entry is a multistep process requiring four cellular receptor, fusion and endocytosis. HCV fusion depends on E1 and E2, viral dose, and occurs within a specific pH range. Targeting pH dependent endocytosis is a useful tool to identify antiviral drugs against. A major advancement to look in...
The dynamic range of the quantitative analysis covered a six-order interval ranging from 100 to 106 genome equivalents per assay. The 95% detection limits were 14 gEq for HIV-1, 10 gEq (1.7 IU) for HBV, and 15 gEq (7.5 IU) for HCV per assay. The proposed approach is considered to ...
NA, not applicable; IQR, interquartile range. a In those with detectable virus. b Batts–Ludwig scoring system. Common transcriptional signatures in liver and PBMC samples from HCV/HIV coinfected patients Using a two-way ANOVA approach, a molecular signature common to liver and PBMC samples ...
Thus, there is currently a need for new anti-viral therapies. In particular there is a need for new antiviral therapies that produce fewer unwanted side-effects, that are more effective against a range of HCV genotypes, or that have less complicated dosing schedules, i.e. that require ...