Chronic Myeloid Leukaemia usually arises from the precursors of myeloid cells which would subsequently, in normal circumstances, evolve into normal white cells. Bone marrow is found inside most of the bones in the body. By adulthood, a large proportion of bone marrow has become relatively inactive....
CML can be classified as being in chronic, accelerated, or blastic phase which impacts both treatment and prognosis. For patients in chronic phase, once the diagnosis is confirmed, therapy with a tyrosine kinase inhibitor (TKI) should be started. Patients should then be monitored serially with a...
浙江大学博士学位论文CML酪氨酸激酶抑制剂分子靶向药物及异基因造血干细胞移植分层治疗研究姓名:***学位级别:博士专业:内科学(血液病学)指导教师:**20120518浙江大学博士学位论文中文摘要CML酪氨酸激酶抑制剂分子靶向药物及异基因造血干细胞移植分层治疗研究浙江大学医学部博士研究生导师内科学(血液病学)罗依黄河教授中文...
Patients whose CML progresses to an advanced phase while on TKI therapy have a worse prognosis than those with de novo advanced-phase CML. Accelerated-phase CML: TKIs are recommended as first-line treatment for patients with newly diagnosed AP-CML In patients with disease progression to AP-CML...
Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003; 102: 276–283. 108 Soverini S, Martinelli G, Rosti G,...
CML prognosis has greatly improved since the development of tyrosine kinase inhibitors (TKIs). Prognosis has shown an association with several clinical characteristics. Many models have been developed to help determine the prognostic risk, including the Sokal index and the Hasford score.7 ...
At present, it is unknown which level of deep molecular response is necessary for optimal prognosis and for successfully stopping therapy. The aim of this work is both to evaluate the technical feasibility of molecular monitoring at the mentioned level and to search for factors allowing to predict...
Prognosis of patients with chronic myeloid leukemia presenting in advanced phase is defined mainly by blast count, but also by age, chromosomal aberrations and hemoglobin. Am J Hematol. 2019;94:1236–43. Article CAS PubMed Google Scholar Suttorp M, Millot F, Sembill S, Deutsch H, Metzler ...
Extreme swing of phosphor from severe hyperphosphatemia to severe hypophosphatemia in a patient with blast crisis of myeloid origin was the result of imbalance between massive apoptosis of leukemic cells in the context of spontaneous tumor lysis syndrome
Chronic myelogenous leukemia: age incidence, duration and benefit derived from irradiation. J Amer Med Ass 1924; 82: 1489–1494. Article Google Scholar Goldman JM, Lu DP . New approaches in chronic granulocytic leukemia—origin, prognosis and treatment. Seminars Hematol 1982; 19: 241–256. CAS...