参考文献 [1] Perrone, Salvatore et al.How has treatment changed for blast phase chronic myeloid leukemia patients in the tyrosine kinase inhibitor era? A review of efficacy and safety[J]. Expert opinion on pharmacotherapy vol. 17,11 (2016)...
blast phase transformationchronic myelogenous leukemianilotinibextramedullary leukemiaObjective We describe the clinical manifestations and management of a patient with lymphoid blast transformation of CML with sole compromise of central nervous system. Design case report Setting Hematology ward of Hospital San ...
Chronic myelogenous leukemia in the lymphoid blastic phase: characteristics, treatment response, and prognosis PURPOSE: To determine the clinical and laboratory characteristics and outcomes of patients with chronic myelogenous leukemia (CML) in the lymphoid blastic ... PM Derderian,HM Kantarjian,M Talpa...
Treatment of chronic myeloid leukemia has improved significantly with the introduction of tyrosine kinase inhibitors (TKIs), and treatment guidelines based on numerous clinical trials are available for chronic phase disease. However for CML in the blast
[CML] Late-onset marrow aplasia due to imatinib in newly diagnosed chronic phase chronic myeloid leukaemiaRob [CML] Patients With Up-Front Cytogenetic Resistance to Imatinib Are Associated With a Greater Likelihood of Progression to Blast CrisisRob ...
CML can progress to blast phase from the chronic or accelerated phase, or in some cases a person is already in the blast phase at the time of diagnosis. Blast phase CML is difficult to control with medications. TREATMENT OF CHRONIC MYELOID LEUKEMIA The most common treatments for CML are: ...
SUMMARY. Fourteen cases of Philadelphia chromosome (Ph 1 ) positive chronic myeloid leukaemia in blast transformation have been investigated using cell surface markers. Morphologically eight cases were lymphoid and the remainder myeloid ... G Janossy,MF Greaves,T Revesz,... - 《British Journal of ...
Treatment protocols for chronic myelogenous leukemia (CML) are provided below for chronic phase, accelerated phase, and blast phase. General treatment recommendations for chronic myelogenous leukemia Tyrosine kinase inhibitors (TKIs) are the drugs of choice for initial therapy of CML. [1] Imatinib was...
(PFS) considered the additional events accelerated phase and blast crisis (BC). Death unrelated to CML was defined as death without prior progression and unrelated to CML-therapy. Death due to CML was stratified according to the European treatment and outcome study (EUTOS)-long-term-survival (...
Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis. Proc Natl Acad Sci U S A. 2003; 11:6694–6699. 25. Medina KL, Garrett KP, Thompson LF, Rossi MI, Payne KJ, Kincade PW. Identification of ...