Blast Phasedoi:10.1007/978-3-642-16483-5_664Last phase of CML, similar to an acute leukemia (poor prognosis). Characterized by >20% myeloblasts or lymphoblasts in blood or bone marrow. NilotinibSpringer Berlin Heidelberg
Blast Phasedoi:10.1007/978-3-540-47648-1_664Last phase of CML; similar to an acute leukemia (poor prognosis). Characterized by >20% myeloblasts or lymphoblasts in blood or bone marrow. NilotinibSpringer Berlin Heidelberg
Blast Phase (blast crisis, blast transformation) refers to the evolution ofCMLintoacute leukemia(CML-BP). Enhanced proliferation and differentiation arrest, the characteristic features of blast transformation in CML, seem to be dependent upon the cooperation ofBCR-ABL1with theTP53(17p13) andRB1(13...
Treatment of chronic myeloid leukemia has improved significantly with the introduction of tyrosine kinase inhibitors (TKIs), and treatment guidelines based on numerous clinical trials are available for chronic phase disease. However for CML in the blast
Musashi2(Msi2)-Numb pathway de-regulation is a molecular mechanism underlying the transition of chronic phase Ph + CML to deadly blast crisis, particularly in cases with a NUP98/HOXA9 fusion from a t(7;11)(p15;p15). This study provides new insights on the mechanisms cooperating in dr...
However resistance to these agents continues to pose challenges for effective CML treatment. Imatinib was the first BCR-ABL inhibitor to be approved for first-line treatment of CML. In a prospective intent-to-treat analysis of patients with chronic-phase (CP) CML who received first-line imatinib...
Kaiso protein has been identified as a new member of the POZ-ZF subfamily of transcription factors that are involved in development and cancer. There is consistent evidence of the role of Kaiso and its involvement in human tumorigenesis but there is no e
The patient was enrolled on a phase 2 study of nilotinib 400 mg twice daily as first line treatment of CML.7 She achieved a major molecular response (BCR-ABL/ABL=0.1% according to the International Scale) after 3 months, but suddenly progressed to lymphoid blast crisis (BC) after 6 ...
are consistent with early B cell origin of the blast cells (TdT+, CD10+, CD19+, CD22+, CD7 neg, so it could be that the recurrent loss of the TCR G/D region in B cells with legitimate IGH rearrangements represents the lineage infidelity as reported previously in blast phase CML [18...
Epub 2013 Mar 29. Comment; Editorial 展开 关键词: Humans Blast Crisis Pyrimidines Thiazoles Antineoplastic Agents Leukemia, Myelogenous, Chronic, BCR-ABL Positive Central Nervous System Neoplasms Hematopoietic Stem Cell Transplantation Male DOI: 10.1159/000347168 被引量: 2 年份: 2013 ...