Better Treatment Options Needed for Patients With CML in Blast PhaseJason HoffmanPharmD
Treatment of chronic myeloid leukemia has improved significantly with the introduction of tyrosine kinase inhibitors (TKIs), and treatment guidelines based on numerous clinical trials are available for chronic phase disease. However for CML in the blast
CMLvasculitisblast crisisEBV-infectionchronic myeloid leukemiaUnless they undergo transplantation, all patients with chronic myeloid leukemia (CML) will eventually develope a late phase of acute blast crisis (ABC). Although additional chromosomal abnormalities to the Philadelphia (Ph) chromosome may herald...
The clinical features, morphologic and cytogenetic findings help in the identification and distinction of megakaryocytic blast phase of CML from Acute Megakayoblastic Leukemia. The diagnosis of such rare presentation of CML is essential for determining the choice of treatment. Therefore including a ...
We know that CML in lymphoid blast crisis can “masquerade” as Ph+ ALL in some cases, but it is generally felt that these account for a very small minority of Ph+ ALL cases. In the most extreme example, patients can “relapse” with CML in chronic phase following treatment of what ...
DISUSSION CML treatment depends on the phase of the disease, age of the patients and their general health. During the chronic phase, the aim of treatment is to control the blood counts to within a normal range and perform a bone marrow transplantation.2 In the blast phase, as the number ...
Chronic myeloid leukemia (CML) is a cancer of the hematopoietic system that is initiated by a single genetic alteration (the BCR-ABL fusion gene or Philadelphia chromosome) and progresses in several phases: during the chronic phase the number of cells grows slowly and the fraction of immature ce...
The mortality in this stage of CML is very high…although some patients do make it through treatment. Heena Satam on December 4, 2015 at 12:24 am So can we say that a blast phase with >20% myeloblast and left shift (i.e. increased neutrophile count) is considererd as AML case?
on therapy are critical in the current management of the disease. Problems facing the diagnostic pathologist in this “Age of Imatinib” include accurate diagnosis and determination of CML disease phase prior to therapy, evaluating response to therapy, and assessing for disease progression on therapy....
CML progresses from a chronic phase (CP) in hematopoietic stem cells (HSC) that harbor the BCR-ABL translation, to blast crisis (BC), characterized by... AE Abrahamsson,I Geron,J Gotlib,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: ...