Clozapine treatment may be complicated by the development of life-threatening agranulocytosis, so regular haematological monitoring is required. To determine the incidence of clozapine-induced agranulocytosis in Australia and the importance of monitoring white blood cell counts in patients treated with ...
Under this shared program, only ANC is used to monitor patients for clozapine-induced neutropenia; white blood cell (WBC) count monitoring is no longer required. In addition, ANC thresholds for clozapine treatment interruption were lowered from previous requirements to allow continued treatment for a...
Second, although clozapine treatment requires additional clinical contact related to white blood cell count monitoring, this study was not designed to determine whether any beneficial effects of clozapine treatment on suicidality are related to this additional contact. However, the equivalent clinical ...
Poster #3 BEYOND WHITE BLOOD CELL MONITORING: SCREENING IN THE INITIAL PHASE OF CLOZAPINE THERAPY Clozapine is the preferred option for treatment-resistant schizophrenia. However, since 1975, clozapine has been known to cause agranulocytosis. In the clo... C Dan,IP Bogers,DV Dijk,... - 《Sc...
A serious drawback to the use of clozapine, however, is the potentially fatal agranulocytosis that is reported to occur in 1 to 2% of unmonitored patients, necessitating weekly white blood cell counts for at least the first 6 months of pharmacotherapy. ...
Clozapine is available only through a distribution system that assures close monitoring of white blood cells. Patients must have white blood cell counts determined before starting treatment, once every week for the first six months, once every other week after that, and once a week for the first...
The ANC is usually available as a component of the complete blood count (CBC), including differential, and is more relevant to drug-induced neutropenia than is the white blood cell (WBC) count. The ANC may also be calculated using the following formula: ANC equals the Total WBC count ...
Other reasons for limited use of clozapine include the extra effort entailed in monitoring white blood cell counts to detect granulocytopenia or agranulocytosis and, possibly, minimal efforts to market it now that it is largely generic. Awareness of the benefits and risks of clozapine is essential...
It also helps guarantee that clozapine is stopped immediately if a patient develops a fall in the white cell count. Since the introduction of the CPMS only one patient has died in UK as a direct result of clozapine-induced agranulocytosis. (Mangan and Toal, 1994). Despite its proven ...
strict adherence to monitoring reduces the incidence to less than 0.5%.99Treatment should not be initiated if the white blood cell count is less than 3500 cells/µL or the absolute neutrophil count is less than 2000 cells/µL, and cell counts should be monitored. A number of cardiovascula...