The clozapine clinic is where people diagnosed with chronic schizophrenia who take the antipsychotic clozapine go for routine monitoring of clozapine side effects, particularly haematological effects. Psychopharmaceutical treatments are often criticized for being reductionistic and dehumanizing, but clozapine ...
Inform patients and caregivers FAZACLO is available only through a restricted program called the Clozapine REMS Program designed to ensure the required blood monitoring, in order to reduce the risk of developing severe neutropenia. Advise patients and caregivers of the importance of having blood tested...
without recurrence of eosinophilia. In the absence of organ involvement, continue CLOZARIL under careful monitoring. If the total eosinophil count continues to increase over several weeks in the
Second, although clozapine treatment requires additional clinical contact related to white blood cell count monitoring, this study was not designed to determine whether any beneficial effects of clozapine treatment on suicidality are related to this additional contact. However, the equivalent clinical ...
With periodic blood monitoring, the agranulocytosis risk is 0.38% (Honigfield G, 1996). Background history Clozapine was introduced in Europe in 1975.As a result of reports from Finland, where 16 patients out of 2260 exposed (0.7%) developed agranulocytosis and 8 (50%) of them ...
If the patient is an inpatient, the ANC must be reported to the clozapine REMS program within 7 days of the most recent blood sample. Patients with BEN can be treated with clozapine and have a separate ANC monitoring algorithm. Also, there are two ANC monitoring algorithms: ...
After adding indirect benefits resulting from increased work productivity (minus indirect costs related to increases in transport costs because of visits for blood monitoring during clozapine therapy), the benefit : cost ratios increased to 2.04 : 1 and 1.48 : 1, respectively. Assuming that clozapine...
Clozapine is available only through a distribution system that ensures monitoring of WBC count and ANC according to the schedule described below prior to delivery of the next supply of medication.|BOXED WARNING: 2. SEIZURES: Seizures have been associated with the use of clozapine. Dose appears to...
The use of clozapine is limited by its occasional production of agranulocytosis, a complication that requires frequent monitoring of white blood cells (Krupp and Barnes, 1992). In addition, there is a significant drug-related incidence of new-onset diabetes mellitus, as well as dyslipidemia and ...
μL for the first 6 months of treatment, monitoring frequency may be reduced to every 2 weeks for the next 6 months. If the ANC remains equal to or greater than 1500/μL for the second 6 months of continuous therapy, ANC monitoring frequency may be reduced to once every 4 weeks ...