Intended use: Clozapine determination kit is an in vitro diagnostic test for the detection of clozapine in human blood. Clozapine is used to treat cer...
With regular blood monitoring, clozapine is the drug of choice for patients with schizophrenia who are unresponsive to or intolerant of previous antipsychotic therapy. Pharmacodynamic Properties The atypical antipsychotic drug clozapine is a tricyclic dibenzodiazepine, whose clinical efficacy is thought to b...
The main reasons for this are that it can cause adverse effects such as weight gain and sedation, and the need for regular blood test monitoring because of the risk of agranulocytosis. While these hurdles are unavoidable, another problem in the UK has been the historical practice of admitting...
monitoring frequency may be reduced to every 2 weeks for the next 6 months. If the ANC remains equal to or greater than 1500/μL for the second 6 months of continuous therapy
Facebook Twitter Google Share on Facebook clozapine Thesaurus Medical Wikipedia clo·za·pine (klō′zə-pēn′, -pĭn) n. An antipsychotic drug, C18H19ClN4, used as a sedative and in the treatment of schizophrenia. [c(h)lo(ro)- + alteration of(dia)zepine,seven-member ring containin...
(Table 2) and are eligible to initiate treatment. Weekly ANC monitoring is required for all patients during the first 6 months of treatment. If a patient’s ANC remains equal to or greater than 1500/μL for the first 6 months of treatment, monitoring frequency may be reduced to ...
However, clozapine remains available in at least 30 countries, in some cases only on special request, for the treatment of severe psychotic disorders unresponsive to other neuroleptics provided that close monitoring of the blood count is feasible. In 1989, it was introduced in the United States ...
Objectives To show the heptotoxicity potential of Clozapine and adress the importance of monitoring the liver function tests in clozapine titration to prevent sever conditions Methods A case report of a fifty-year old Tunisian male patient diagnosed with resistant schizophrenia who developed a hepat...
spread in her upper extremities and 4+ with spread in her lower extremities. The results of arterial blood gas analysis were normal, and the results of serum and urine toxicology studies were negative. All additional serologic test results, including those for complete blood count, chemistry, ...
thereafter monthly monitoring is considered satisfactory. Clozapine is contraindicated in conjunction with drugs with the potential to depress bone marrow function/induce agranulocytosis, as well as in patients with severe CNS depression, myeloproliferative disorders or a history of drug-induced agranulocyt...