But, to our knowledge, this study is the first to monitor DRs on brain-resident cells and infiltrating immune cells during EAE. Here, we show that all five DR are present on brain-resident microglia, although the levels were lower than on other myeloid cells (i.e. monocytes, and ...
The provision of these antibodies which substantially selectively react with clozapine and do not cross react with N-desmethylclozapine and clozapine-N-oxide allows one to produce an immunoassay which can specifically detect and quantify so as to monitor clozapine in the fluid samples of patients bein...
Activity was evaluated in transparent (47.6 Â 25.4 Â 20.6 cm3 high) polystyrene enclosures using a computerized photobeam system (MotorMonitor Kinder Scientific). Animals were placed in the enclosures 20 min after drug administration, and activity was monitored for 1 h. Locomotor activity was...
(v) manual maneuvers to facilitate at least 25% of defecations (e.g., digital evacuation, support of the pelvic floor); (vi) fewer than three defecations per week; laxative use as a proxy measure for constipation; radiological evaluation by measures such as the colonic transit test; and,...