It has been shown previously that innate and adaptive immune cells are increased in the CNS and that pro-inflammatory cytokines, like interferon gamma and interleukin-17, associated with a high level of inflammation are upregulated5,6,7. We have shown previously that clozapine treatment reduces ...
*Significant post hoc comparisons of simple main effects between Egr3À/À and WT mice at the dose leading to an extreme reduction in activity in WT controls (a and c) or Student's t-test after Bonferroni correction for multiple comparisons (b and d) (*po0.005; **po0.001). level ...
Psychiatrists wish they could give clozapine to everyone who needs an antipsychotic. They can’t, because its increased efficacy goes side-by-side with greater side effects. The best known are agranulocytosis, metabolic syndrome, seizures, myocarditis, and eosinophilia, and the list just goes on ...
Additionally, we extracted further data where possible to assess the study-level factors associated with constipation prevalence in clozapine-treated patients. The data collected from each article included: study design, geographical location, study setting, method of constipation assessment, constipation ...