Mechanism of action in the management of OCD unknown but may involve inhibition of reuptake of serotonin. Desmethylclomipramine inhibits norepinephrine reuptake; therefore, clomipramine also shares pharmacologic
Clomipramine (Anafranil) is a psychotropic agent used to treatobsessive-compulsive disorder(OCD). Clomipramine shares structural similarities with a class ofantidepressantsknown as tricyclic antidepressants (TCAs). The exact mechanism by which clomipramine exerts its therapeutic benefits is not fully underst...
Clomipramine in obsessive–compulsive disorder. Archives of General Psychiatry. 1989; 46 :23–28.Benkelfat C, Murphy DL, Zohar J, et al. Clomipramine in obsessive-compulsive disorder. Further evidence for a serotonergic mechanism of action. Arch Gen Psychiatry. 1989; 46 :23–8....
The actual neurochemical mechanism is unknown, but CMI’s capacity to inhibit the reuptake of serotonin (5-HT) is thought to be important. Pharmacokinetics Absorption/Bioavailability CMI from clomipramine hydrochloride capsules is as bioavailable as CMI from a solution. The bioavailability of CMI from...
Beware, for those who tread this path in the bloom of youth, as the shadow of suicidal thoughts may loom closer, requiring vigilant surveillance of the mind's labyrinthine twists and turns. What is the mechanism of action for clomipramine (also known as the generic version of Anafranil)?