Mechanism of action in the management of OCD unknown but may involve inhibition of reuptake of serotonin. Desmethylclomipramine inhibits norepinephrine reuptake; therefore, clomipramine also shares pharmacologic profile of other tricyclic antidepressants. Exhibits marked anticholinergic activity, which may ...
Clomipramine in obsessive-compulsive disorder. Further evidence for a serotonergic mechanism of action. Arch Gen Psychiatry. 1989;46(1):23-8.Benkelfat C, Murphy DL, Zohar J, Hill JL, Grover G, Insel TR. Clomipramine in obsessive-compulsive disorder. Further evidence for a serotonergic me...
Because other tricyclic antidepressants do not increase 5-HTP-mediated cortisol release, it seems unlikely that enhancement of 5-HT 2 receptor function is a critical mechanism for antidepressant action. However, facilitation of neurotransmission at 5-HT 2 receptors could account for the efficacy of ...
The selective response of OCD patients to clomipra- mine or SSRIs has led to the hypothesis that changes in the central serotonergic systems may be the mechanism by which these compounds exert their effect (Leonard et al, 1988; Goodman et al, 1990, 1992; Baumgarten and Grozdanovic, 1998)...
Beware, for those who tread this path in the bloom of youth, as the shadow of suicidal thoughts may loom closer, requiring vigilant surveillance of the mind's labyrinthine twists and turns. What is the mechanism of action for clomipramine (also known as the generic version of Anafranil)?