Mechanism of action in the management of OCD unknown but may involve inhibition of reuptake of serotonin. Desmethylclomipramine inhibits norepinephrine reuptake; therefore, clomipramine also shares pharmacologic profile of other tricyclic antidepressants. Exhibits marked anticholinergic activity, which may ...
Clomipramine is different from the other TCAs, exhibiting preferential selectivity for inhibiting the reuptake of 5-HT at the presynaptic neuronal membrane. Its antidepressant mechanism of action as an inhibitor of the 5-HT transporter is reduced in vivo, however, because of the formation of its ac...
ClomipramineGeneric NameGeneric NameClomipramineBrand NameBrand NameAnafranilClassClassTricyclic antidepressantProposed Mechanism(s) of ActionProposed Mechanism(s) of ActionBoosts neurotransmitters serotonin anddoi:10.1007/978-0-387-79948-3_1639John C. Courtney...
10.The Protective Effects of Imipramine on Focal Cerebral Ischemia-reperfusion Injury and Its Mechanism of Action in Rats;米帕明对大鼠脑缺血再灌注损伤保护作用及其机制 11.Effect of verapamil on the permeability of the P-glycoprotein substrate rhodamine 123 across the jejunal membranes维拉帕米对P-糖蛋白...
Clomipramine in Obsessive-Compulsive Disorder: Further Evidence for a Serotonergic Mechanism of Action Data from several previous studies link clomipramine's potent serotonergic effects to its clinical efficacy in reducing the symptoms of obsessive-compulsiv... Benkelfat,Chawki - 《Arch Gen Psychiatry》 ...
Because other tricyclic antidepressants do not increase 5-HTP-mediated cortisol release, it seems unlikely that enhancement of 5-HT 2 receptor function is a critical mechanism for antidepressant action. However, facilitation of neurotransmission at 5-HT 2 receptors could account for the efficacy of ...
Additionally, clomipramine is characterized by a broad pharmacological spectrum of actions including a1-adrenolytic, anticholinergic, and weak antihistaminergic and antiserotonergic (serotonin-receptor blocking) properties. The actual neurochemical mechanism is unknown, but clomipramine's capacity to inhibit ...
Beware, for those who tread this path in the bloom of youth, as the shadow of suicidal thoughts may loom closer, requiring vigilant surveillance of the mind's labyrinthine twists and turns. What is the mechanism of action for clomipramine (also known as the generic version of Anafranil)?
Because other tricyclic antidepressants do not increase 5-HTP-mediated cortisol release, it seems unlikely that enhancement of 5-HT2 receptor function is a critical mechanism for antidepressant action. However, facilitation of neurotransmission at 5-HT2 receptors could account for the efficacy of ...
Further evidence for a serotonergic mechan- ism of action. Arch Gen Psychiatry 46: 23-28.Benkelfat C, Murphy DL, Zohar J, et al. 1989. Clomipramine in obsessive- compulsive disorder. Further evidence for a serotonergic mechanism of action. Arch Gen Psychiatry, 46:23-8....