Clomipramine is different from the other TCAs, exhibiting preferential selectivity for inhibiting the reuptake of 5-HT at the presynaptic neuronal membrane. Its antidepressant mechanism of action as an inhibitor of the 5-HT transporter is reduced in vivo, however, because of the formation of its ac...
ClomipramineGeneric NameGeneric NameClomipramineBrand NameBrand NameAnafranilClassClassTricyclic antidepressantProposed Mechanism(s) of ActionProposed Mechanism(s) of ActionBoosts neurotransmitters serotonin anddoi:10.1007/978-0-387-79948-3_1639John C. Courtney...
Mechanism of action in the management of OCD unknown but may involve inhibition of reuptake of serotonin. Desmethylclomipramine inhibits norepinephrine reuptake; therefore, clomipramine also shares pharmacologic profile of other tricyclic antidepressants. Exhibits marked anticholinergic activity, which may ...
The exact mechanism by which clomipramine exerts its therapeutic benefits is not fully understood. However, similar to other TCAs, clomipramine is thought to enhance the actions of norepinephrine and serotonin (chemical neurotransmitters in the brain that nerves use to communicate with one another) by ...
The principle mechanism of action of clomipramine is potentiation of the effects of #-HT and noradrenaline in the brain by inhibiting their neuronal reuptake La clomipramina agisce principalmente potenziando gli effetti della #-HT e della noradrenalina a livello cerebrale, inibendo la loro ric...
Background The central serotonergic system has been implicated in the pathophysiology of depression and in the mechanism of the action of antidepressant drugs. The human platelet has been proposed as a peripheral model of central serotonergic neurons. Methods Six peripheral serotonergic parameters were de...
Beware, for those who tread this path in the bloom of youth, as the shadow of suicidal thoughts may loom closer, requiring vigilant surveillance of the mind's labyrinthine twists and turns. What is the mechanism of action for clomipramine (also known as the generic version of Anafranil)?
Previously, we have shown that in vitro antidepressants modulate glucocorticoid receptor (GR) function and expression, and have suggested that these effects could be relevant for the mechanism of action of antidepressants. To further clarify the interaction between antidepressants and glucocorticoids, we ...
The action of clomipramine and imipramine on induced IFN-gamma and anti-myelin antibodies suggests that the mechanism for the suppressive effect of those substances on EAN symptoms may be due to an action on myelin T and B cell autoreactivity. Considering that the main common pharmacological ...
CLOMIPRAMINE-INDUCED HYPOSENSITIVITY OF SEROTONIN RECEPTORS AS A POSSIBLE MECHANISM FOR ANTIDEPRESSANT ACTION, BEHAVIOURAL STUDYdoi:10.1016/B978-0-08-023768-8.50883-5P. LESIEURJ. COSTENTINJ.C. SCHWARTZAbstracts