In a previous study of untreated patients with OCD, we found no differences in the behavioral response to single-dose administration of metergoline or placebo. In the present study, patients with OCD receiving clomipramine hydrochloride on a long-term basis (with an average 40% lessening in...
In children <15 years of age, plasma concentration-dose ratios of clomipramine are substantially lower than those of adults.In smokers, steady-state plasma clomipramine concentrations are substantially lower than in nonsmokers; smoking appears to have less effect on plasma concentrations of desmethyl...
Define clomipramine. clomipramine synonyms, clomipramine pronunciation, clomipramine translation, English dictionary definition of clomipramine. n. A tricyclic antidepressant drug, C19H23ClN2, used in the form of its hydrochloride salt primarily to treat
DOSE/DURATION : 357 ug/kg TOXIC EFFECTS : Gastrointestinal - nausea or vomiting REFERENCE : JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1981- Volume(issue)/page/year: 2,215,1982 TYPE OF TEST : TDLo - ...
The aim was to assess the effect of a flexible dose of paroxetine, compared with clomipramine and placebo, in obsessive-compulsive disorder (OCD).In a multinational randomised study, 406 subjects with OCD of at least six months duration received double-blind medication for up to 12 weeks. Dos...
for up to 1 year without loss of benefit. However, dosage adjustments should be made to maintain the patient on the lowest effective dosage, and patients should be periodically reassessed to determine the need for treatment. During maintenance, the total daily dose may be given once daily at ...
The tricyclic antidepressant clomipramine dose-dependently reduces regional cerebral metabolic rates for glucose in awake rats The time course and the relation to dose of regional cerebral metabolic rates for glucose (rCMRglc) were measured in awake male Fischer-344 rats after admi... U Freo,P Pie...
To lessen the side effects such as a stomach upset or dizziness, clomipramine medicine will be advised in a low dose but given with several meals. The dosage will increase slowly and gradually as your body gets used to it. Once you reach the best dose required for you, you can take ...
Participants were adult outpatients (N=122 entrants) with OCD. Interventions included intensive exposure and ritual prevention for 4 weeks, followed by eight weekly maintenance sessions, and/or clomipramine administered for 12 weeks, with a maximum dose of 250 mg/day. The main outcome measures were...
Orthostatic hypotension, the clinically most important side effect in treatment with tricyclic antidepressants, was investigated in a double-blind study with clomipramine and the selective serotonin reuptake inhibitor citalopram given for 5 wk. All patients were initially given placebo for 1 wk. In the...