Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity of multiple sclerosis (MS) in a reliable and valid way. There
There were a few active comparator clinical trials, including conventional medications, cognitive behavioral therapy, and another herbal formula. For mild Alzheimer’s disease, ischemic stroke, and amyotrophic lateral sclerosis, herbal medicines were tested for add-on therapy in addition to standard ...
papers includes topics such as: biomarker discovery; approaches for more accurate diagnostics; assessment of clinical heterogeneity and in more diverse cohorts; clinical trials, both observational and interventional, as well as case studies. Preclinical work would not be within scope for this collection...
Ferumoxytol is also being studied in a number of clinical trials (TableI) for the imaging of a variety of diseases and conditions, ranging from: multiple sclerosis to numerous cancers (e.g. prostate, bladder, breast, lung, ovarian, to name a few) to heart conditions to type 1 diabetes. ...
Trials volume 24, Article number: 638 (2023) Cite this article 1570 Accesses Metrics details Abstract Background The extent of resection of glioma is one of the most important predictors of the survival duration of patients after surgery. The presence of eloquent areas within or near a tumor ...
Moreover, these researchers stated that to suggest the routine use of nHFOV as an initial therapy in the management of preterm neonates, further studies, especially multi-center trials, are needed. The authors stated that this study had several drawbacks. First, the number of subjects in this ...
Moreover, these researchers stated that large controlled trials are needed to identify the subset of patients who would benefit the most from this technique.The authors stated that this study had several drawbacks. G-POEM is a relatively new technique and the studies that reported the outcome of...
Secondary progressive multiple sclerosis MS: Multiple sclerosis BBB: Blood-brain barrier UCHL1: Ubiquitin carboxyl-terminal esterase L1 EAE: Experimental autoimmune encephalomyelitis SAD: Single ascending dose MAD: Multiple ascending dose R/R NHL: Relapsed/refractory non-Hodgkin’s lymphoma) ...
Sobanski V, Giovannelli J, Allanore Y, Riemekasten G, Airò P, Vettori S, et al. Phenotypes determined by cluster analysis and their survival in the prospective European Scleroderma Trials and Research cohort of patients with systemic sclerosis. Arthritis Rheumatol. 2019;71(9):1553–70. ...
(evobrutinib, fenebrutinib) had no significant impact compared with the placebo, and the trials failed to reach the primary endpoint [111,112]. Several other clinical trials evaluating the efficacy of multiple Btk inhibitors for the treatment of LN are currently underway, and hopefully, positive...