Multiple sclerosis (MS) is a complex immune‐mediated disease characterized by recurrent demyelinating episodes of the central nervous system, which is the most common disabling neurological disease of young people. Cognitive impairment is common and one of the disabling symptoms of MS, resulting in ...
Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess the true efficacy of interventions in clinical trials. In phase III trials in MS, the traditionally...
Also referred to as clinical research or research studies, clinical trials are well-designed studies that collect information about diseases, disorders, and health conditions through the help of human volunteers, as opposed to animal studies, which are known as preclinical research studies. Many ...
Design strategies in multiple sclerosis clinical trials. The Cyclosporine Multiple Sclerosis Study Group. Ann Neurol 1994; 36 Suppl: S108-12.G. W. Ellison, L. W. Myers, B. D. Leake et al., "Design strategies in multiple sclerosis clinical trials," Annals of Neurology, vol. 36, pp. ...
The future of multiple sclerosis therapies: redesigning multiple sclerosis clinical trials in a new therapeutic era. Due to past success in testing and gaining regulatory approval for a variety of therapies in multiple sclerosis (MS), the conduct of future clinical trials... H Mcfarland,S ...
(S1PR5) receptor modulator, and was compared to the first-line treatment, Avonex (interferon beta-1a) (IFN), in patients with relapsing multiple sclerosis (RMS). The findings from the two pivotal phase 3 (SUNBEAM and RADIANCE Part B) trials pave the way for ozanimod to enter the New ...
The conversation revolves around the challenges and potential solutions for implementing personalized medicine in multiple sclerosis (MS) clinical trials. Despite the importance of personalized treatment approaches, current trials typically employ a 1-size-fits-all methodology, lacking personalized recruitment ...
Conventional magnetic resonance imaging (cMRI) is widely used for diagnosing multiple sclerosis (MS) and as a paraclinical tool to monitor disease activity and evolution in natural history studies and clinical trials. However, the correlation between cMRI and clinical findings is far from strict, ...
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Background: Phase 3 clinical trials for disease-modifying therapies in relapsing-remitting multiple sclerosis (RRMS) have utilized a limited number of conventional designs with a high degree of success. However, these designs limit the types of questions that can be addressed, and the time and cos...