Phase IIA clinical trials are commonly conducted as pilot studies to evaluate efficacy and safety in selected populations of patients with the disease or condition to be treated or prevented. The efficacy objective is to find preliminarily evidence of the effectiveness or ineffectiveness of study ...
A phase IIa clinical trial of first-line cyclical therapy alternating gemcitabine, cisplatin, and durvalumab with pemigatinib for advanced biliary tract cancers withFGFR2-alterations. doi:10.1200/JCO.2025.43.4_suppl.TPS64543TPS645#Background:Unresectable biliary tract cancer (BTC) has a poor ...
INTRODUCTION AND OBJECTIVES We performed phase IIa clinical trial of NMK36, a novel PET tracer containing a synthetic amino acid analogue trans-1-amino-3-18F-fluoro-cyclobutyl-carboxylic acid (anti-18F-FACBC), in patients with metastatic prostate cancer. The aim of this trial was to evaluate ...
EA‐230 has shown promising immunomodulatory and tissue‐protective effects in animals and an excellent safety profile in human phase I studies that we performed. The present phase IIa study follows‐up on these results by investigating the safety, efficacy and pharmacokinetics of EA‐230 under ...
摘要: [18F]Fluciclovine (anti-[18F]FACBC) has demonstrated diagnostic efficacy for cancers of the brain where [18F]fludeoxyglucose has limitations. We conducted a phase IIa study of anti-[18F]FACBC to asses关键词: Clinical trial 18F]Fluciclovine Glioblastoma Positron emission tomography Magnetic...
In a pilot phase IIa-b clinical trial MemSID, memantine, a blocker of NMDAR, was used for treatment of four patients for 12 months. Two more patients that have enrolled into the study did not finish it. One of them had psychotic event following the involuntary overdose of the drug, ...
et al. Phase-IIa randomized, double-blind, sham-controlled, parallel group trial on anodal transcranial direct current stimulation (tDCS) over the left and right tempo-parietal junction in autism spectrum disorder—StimAT: study protocol for a clinical trial. Trials 22, 248 (2021). https://...
A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopeniaLOWER-EXTREMITY FUNCTIONVITAMIN-DOLDER-ADULTSAMINO-ACID
FRAME: A Phase I Study of Avutometinib (VS-6766) + Defactinib in Patients with Advanced Solid Tumors This is a multi-centre, investigator-initiated, dose escalation, Phase I trial of the combination of the FAK inhibitor, Defactinib (VS-6063), and the dual RAF/MEK inhibitor, avutometinib...
CPL-01 is an extended-release injectable version of ropivacaine hydrochloride developed by Cali Biosciences to treat post-operative surgical pain and reduce the need for opioids. The phase IIa clinical trial of CPL-01 in abdominoplasty is a randomized, double-blin...