In the conduct of a phase II cancer clinical trial, patients usually enter in two stages. If the response rate from the first stage is low, then the study terminates. Within various two-stage designs, Simon proposed the optimal and minimax criteria. In the co-operative group setting, ...
[7] Oncorena's first patient treated with ONC175 (orellanine) in clinical phase I/II trial in patients with metastatic renal cancer and dialysis at Karolinska University Hospital in Stockholm, Sweden r. Retrieved September 5,2023,from https://www.prnewswire.com/news-releases/oncorenas-first-...
近日,南京鼓楼医院刘宝瑞教授和杜娟教授担任通讯作者在Frontiers in Immunology(2022年IF=7.3)在线发表“Efficacy and safety of second-line therapy by S-1 combined with sintilimab and anlotinib in pancreatic cancer patients with liver...
PhaseIIClinicalTrials MiguelVillalona-Calero,MD.,FACPTheOhioStateUniversity Question •WhatpercentageoftheconceptssubmittedbyyouarePhase2trialsorthePhase2trialisitsmaincomponent?a.20%b.40%c.50%d.60% InteractiveAnswer Overview I.Objectives&ConceptDevelopmentII.DesignIII.EndpointsOutcomesMeasuresIV.SampleSize...
Sagopilone is a novel fully synthetic epothilone with promising preclinical activity and a favourable toxicity profile in phase I testing. A phase II pharmacokinetic and efficacy trial was conducted in patients with metastatic melanoma. Patients had meas
First Patient Dosed in Phase 1/2 Clinical Trial Evaluating CFT1946, an Orally Bioavailable BiDAC™ Degrader, in BRAF V600 Mutant Solid Tumors. Retrieved February 3, 2023, from https://ir.c4therapeutics.com/news-releases/news-release-details/c4-therapeutics-announces-first-patient-dosed-phase-...
These contributions significantly enhance the design of phase III trials, ultimately leading to the efficient utilization of clinical trial resources. 展开 关键词: Humans Ovarian Neoplasms Brain Neoplasms Treatment Outcome Sickness Impact Profile Cognition Clinical Trials, Phase II as Topic Neoplasms Patient...
Nezhat FW, Wadler S, Runowicz C et al. Phase II clinical trial of bryo- statin-1 (NSC 339555), and cisplatin in patients with recurrent and/or advanced inoperable squamous cell, adeno, or adenosquamous cell carcinoma of the cervix. Proc Am Soc Clin Oncol 2002; 21:...
Background: Laboplatin, D-19466, 1,2-diaminomethylcyclobutaneplatinum(II) lactate, is a novel, water-soluble platinum complex which showed a better therapeutic index than Cisplatin or Carboplatin in murine and human tumor models. In a preceding Phase I study myelosuppression with predominant thromboc...
2. 阿昔替尼联合特瑞普利单抗用于粘膜黑色素瘤的新辅助治疗的II期临床研究 A phase 2 clinical trial of neoadjuvant anti-PD-1 ab (Toripalimab) plus axitinib in resectable mucosal melanoma. AUTHOR(S) Chuanliang Cui, Xuan Wang, Bin Lian, Lu Si, Zhihong Chi, Xinan Sheng, Yan Kong, Lili Mao,...