Synonyms Controlled clinical trial Definition Phase II clinical trials are designed to assess both safety and efficacy of new medications or new uses of existing medications. Subjects are patients with the disorder that the medication is intended to treat. There are usually rigorous inclusion and ...
Define phase II trial. phase II trial synonyms, phase II trial pronunciation, phase II trial translation, English dictionary definition of phase II trial. n. 1. Law a. A proceeding in which opposing parties in a dispute present evidence and make argument
Define phase II. phase II synonyms, phase II pronunciation, phase II translation, English dictionary definition of phase II. Noun 1. phase II - a clinical trial on more persons than in phase I; intended to evaluate the efficacy of a treatment for the con
The primary endpoint in the Phase I part is toxicity, the primary endpoint in the Phase II part is progression-free survival. Discussion With conventional photon irradiation treatment of recurrent rectal cancer is limited, and the clinical effect is only moderate. With carbon ions, an improved out...
For our information, this is the first phase I/II clinical trial to evaluate the anti-inflammatory effect of EGCG in cancer patients with COVID-19 pneumonia. In this Phase I/II trial, we found that atomized EGCG for cancer patients with COVID-19 was well tolerated. We conducted a dose-...
Osimertinib and Bevacizumab Cotreatment for Untreated EGFR-Mutated NSCLC With Malignant Pleural or Pericardial Effusion (SPIRAL II): A Single-Arm, Open-Label, Phase 2 Clinical Trial 2022, JTO Clinical and Research Reports Citation Excerpt : In the WJOG8715L (A phase I study of osimertinib with ...
In this multi-center phase II trial, we evaluated the efficacy and safety of a quadruplet regimen (pembrolizumab, trastuzumab, and doublet chemotherapy) as first-line therapy for unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (AGC) (NCT...
This is an open-label Phase 2 clinical trial evaluating the safety and efficacy of the Hh inhibitor, vismodegib (GDC-0449), in combination with chemotherapy gemcitabine and nab-paclitaxel in patients with previously untreated metastatic PDA. Patients were enrolled at three different institutions: the...
(Caporali et al., 2010). Due to these unique characteristics of this molecule, Milciclib is considered more advantageous keeps over otherCDKs inhibitors. Recently, in 2020 Tiziana Life Science filed a patent on the use of Milciclib (Phase II clinical trial) in combination withtyrosine kinase...
Phase I Clinical Studymeans, as to a particular Licensed Product, an initial clinical study in humans with the purpose of assessing the Licensed Product’s safety, tolerability, toxicity, pharmacokinetics or other pharmacological properties. Phase 1 Clinical Trialmeans a Clinical Trial of a Product ...