After that, we study in details the application of classification to a critical problem in drug discovery, i.e., drug-target prediction, due to the challenges in predicting possible interactions be-tween drugs and targets.doi:10.1142/9789814551014_0008Jian-Ping Mei...
The ability to predict the interaction of drugs with target proteins is essential to research and development of drug. However, the traditional experimental paradigm is costly, and previous in silico prediction paradigms have been impeded by the wide ran
In 2015, it was suggested that a third of drug approvals correspond to repurposing studies If we are to be prepared for future pandemics, we must challenge the ‘one drug−one target’ paradigm. We cannot rely on magic bullets with specific targets — rather, we...
We hereby propose a new drug classification based on the kind of target. Drugs may be directed at tumour cells or other elements involved in carcinogenesis, i.e., the endothelium and extracellular matrix, and the immune system. Potential host cells such as the bone may also be targeted. Tabl...
The SuperPred web server connects chemical similarity of drug-like compounds with molecular targets and the therapeutic approach based on the similar property principle. Since the first release of this server, the number of known compound-target interactions has increased from 7000 to 665,000, which...
The U.S. Food and Drug Administration (FDA) approves new drugs every year. Drug targets are some of the most important interactive molecules for drugs, as they have a significant impact on the therapeutic effects of drugs. In this work, ... Hui-Heng,Lin,Le-Le,... - 《Scientific Report...
The SuperPred web server connects chemical similarity of drug-like compounds with molecular targets and the therapeutic approach based on the similar property principle. Since the first release of this server, the number of known compound-target interactions has increased from 7000 to 665 000, which...
currentlyexistandthereareabout480validatedtargets thatareaddressed(3).Thereareestimationsaboutthe numberofmedicaltargetsbetween2200and3000that favourinteractionswithdrug-likechemicalcompounds (4).Tomapthesemedicaltargetsontomedicalindication areasaclassificationschemeisneeded. ...
Drug-drug interactions (DDIs) may trigger adverse drug reactions, which endanger the patients. DDI identification before making clinical medications is critical but bears a high cost in clinics. Computational approaches, including global model-based and
p pBackground/p pProtein-protein interactions (PPIs) are challenging but attractive targets of small molecule drugs for therapeutic interventions of human ... N Sugaya,K Ikeda - 《Bmc Bioinformatics》 被引量: 52发表: 2009年 Development of a classification system for drug-related problems in the...