A great new drug molecule is discovered from a newly identified bacterium. An enantiomer is quickly synthesized by chemists at a very low cost. Discuss the implications. With natural selection, how can the use of antibiotics result in resistant bacteria?
[99] identified variations in the risks of death from index and non-index cancers among primary cancer locations. It should be cautioned that assessments by PMR may not always be reliable due to a lack of information about the populations at risk. Therefore, even though the denominator or ...
Terpenoids, as represented by more than 40000 identified compounds, are among the most widespread group of natural products, with several new compounds being discovered every year. Terpenes can be generally defined as a group of molecules whose structure is based on various but definite number of ...
Wallner B, Elofsson A (2003) Can correct protein models be identified? Protein Sci 12(5):1073–1086 Article CAS PubMed PubMed Central Google Scholar Wang X, Tang C, Zhang G, Li Y, Wang C, Liu B, Qu Z, Zhao J, Han Q, Huang L, Chen X, Kang Z (2009) cDNA-AFLP analysis rev...
Added to its relation with IDH, CaM-dependent kinase II CaMKK2) is disclosed to be identified differentially in both wild type and mutant type IDH glioblastoma cells which may explain a contribution in modulating the biological behavior of glioma [66]. Trying to disrupt the binding of CaM and...
One example of this design process utilization is the smart autoinjector design platform (Figure 2). The autoinjector is a medical device built around DfE guidelines to reduce its environmental footprint and address areas of improvement for product sustainability identified in many drug delivery device...
Similarly, chimeric antigen receptor (CAR) T-cell therapy may result in lineage drift or switch to myeloid disease [21]. Recent studies have identified ALL cases with alternate fusions that result in a similar gene expression profile: rearrangement of the zinc finger ZNF362 to SMARCA2 and TAF15...
Identified aberrations in the neural substrates of reward and salience processing, response inhibition, interoception , and executive functions with neuroimaging can inform the development of pharmacological, neuromodulatory, and psychotherapeutic interventions to modulate the disordered neurobiology . Neuroimaging...
We identified three different settings: neoadjuvant and adjuvant settings as well as theassociation of systemic therapy with surgery in the metastatic renal cell carcinoma patients. Neoadjuvanttarget therapy with tyrosine kinase inhibitor may facilitate the tumor resection and reduce theoverall tumor ...
With the expanding knowledge of microbial biochemistry and genetics, it has now become possible to identify important microbial enzymes, receptors and processes at the molecular level that might be suitable targets for drug action. Compounds are identified that block the functioning of these targets ...