We investigated the genome-wide expression of the inflammatory phenotype in dendritic cells. Dendritic cells are a complex group of cells that play a critical role in vertebrate immunity. Therefore, the prediction of the inflammatory phenotype in these cells may help with the selection of immune-...
Single-cell RNA sequencing can reveal valuable insights into cellular heterogeneity within tumour microenvironments (TMEs), paving the way for a deep understanding of cellular mechanisms contributing to cancer. However, high heterogeneity among the same
pDCs, plasmacytoid dendritic cells. b, A line plot showing the relationship between classification accuracy and confidence score threshold. X1, fitted coefficient for linear regression between classification accuracy and confidence score; pval, P value for the coefficient. c, Representative examples of ...
Their interactions with immune cells, including dendritic cells, granulocytes, macrophages, Langerhans cells, αβΤ cells, and B cells, are closely related to their anti-infective function (Fig. 3) [57]. Fig. 3 Immunological function of γδT cells. A Antibody-dependent cytotoxicity; B ...
Renal cell carcinoma (RCC), exhibiting remarkable heterogeneity, can be highly infiltrated by regulatory T cells (Tregs). However, the relationship between Treg and the heterogeneity of RCC remains to be explored. Methods We acquired single-cell RNA-seq profiles and 537 bulk RNA-seq profiles of ...
Revealing the profile of myeloid cells residing leukemic TME The malignant leukemia cells in the bone marrow (BM) profoundly remodel the microenvironment and interact profoundly with immune cells. The frequent appearance of myeloid immune cells in leukemia TME, such as dendritic cells, macrophages, and...
Similar subsets of principal cells were recognized in all species examined. Five subgroups were distinguished on the basis of the position of dendritic fields. Although the dendrites of most labeled cells were confined to the medial nucleus of the trapezoid body, some principal cells had dendrites ...
Dendritic cells activated by in... AD Luster - 《Current Opinion in Immunology》 被引量: 833发表: 2002年 Chemokines, inflammation and the immune system. Although there is no evidence that chemokines play a role in the induction of immune reactions, they undoubtedly promote the effector limb of...
examination of which enables the cell of origin to be determined. The different subtypes of leukemia are classified according to this presumed cell of origin, along with the clinical behavior, such that patients with acute disease, where the clone of leukemic cells is highly malignant, tend to ...
Hochweller K, Miloud T, Striegler J, Naik S, Hämmerling GJ, Garbi N: Homeostasis of dendritic cells in lymphoid organs is controlled by regulation of their precursors via a feedback loop. Blood 2009, 114: 4411–4421.Hochweller K., Miloud T., Striegler J., Naik S., Hämmerling G....