pDC are considered to be "professional" type I IFN-producing cells and produce 10- to 100-fold more IFN-α than other cell types in response to enveloped viruses or synthetic TLR7 and TLR9 agonists. In this study, purified pDC were found to express high levels of IFN-λ receptor mRNA, ...
dendritic cell (DC) populations was critical for the development of protective IAV-specific CD8+T cell responses. Mice lacking the IFN-λ receptor (Ifnlr1−/−) had blunted CD8+T cell responses relative to wild type and exhibited reduced survival after heterosubtypic IAV re-challenge. ...
Crucial Role of the Interleukin 1 Receptor Family Member T1/St2 in T Helper Cell Type 2–Mediated Lung Mucosal Immune Responses T1/ST2 is an orphan receptor of unknown function that is expressed on the surface of murine T helper cell type 2 (Th2), but not Th1 effector cells. In vitr.....
Dendritic cell (DC)-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a type II transmembrane C-type lectin expressed on DCs such as myeloid DCs and monocyte-derived DCs (MoDCs). Recently, we have reported that DC-SIGN interacts with carcinoembryonic antigen (CEA) ...
In this study we compare the use of Xcl1 and Ccl3-fusion DNA vaccines for the induction of immune responses against influenza A hemagglutinin (HA). Xcl1 is a ligand of the receptor Xcr1, which is selectively expressed on conventional dendritic cell type 1 (cDC1)25,26. In contrast, Ccl...
Dendritic cells are the primary cell type to initiateT cellresponses to foreign antigens. These cells are stationed throughout all peripheral tissues and express a wide variety of molecularpattern recognition receptorssuch as toll-like receptors (TLRs) and C-type lectins that bind to a variety of...
Dutertre CA, Wang LF, Ginhoux F (2014) Aligning bona fide dendritic cell populations across species. Cell Immunol 291(1–2):3–10. doi:10.1016/j.cellimm.2014.08.006 Article CAS PubMed Google Scholar Shortman K, Heath WR (2010) The CD8+ dendritic cell subset. Immunol Rev 234(1):18...
2003. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity. 19:225-234. http://dx.doi.org/10.1016/S1074-7613(03)00208-5Plasmacytoid Dendritic Cells Induce Plasma Cell ... G Jego,AK Palucka,JP Blanck,... - Elsevier 被引量: 0...
Blood CD83+ cells had a cellular morphology characteristic of dendritic cells and a cell surface phenotype that did not correlate with that of T cells, B cells, NK cells, or cells of the myelomonocytic lineage. Analysis of CD83+ cells with a panel of mAbs that identify 126 leukocyte cell ...
[17] and is endowed with a high intrinsic capacity to cross‐present antigens via MHC class I and the abilities to activate CD8+T cells and promote T helper type 1 (Th1) and natural killer cell responses through IL‐12. The secretion of XCL1, the unique known ligand of XCR1, by ...