Figure 4. Examples of class 1a antiarrhythmics. • Toxicity: Class 1a drugs all have subclass-wide adverse effects and toxicity profiles. They include ventricular arrhythmias and muscarinic antagonism, as well as nausea, vomiting, and diarrhea (in up to 30% of patients). Individual drugs can ...
Quinidine, procainamide and disopyramide are antiarrhythmic drugs in the class 1A category. These drugs have a low toxic to therapeutic ratio, and their use is associated with a number of serious adverse effects during long term therapy and life-threatening sequelae following acute overdose. Class 1A...
Table 6. Possible DDIs of bempedoic acid and cardiovascular drugs. Safe co-administration can also be predicted with antiarrhythmic agents, while the systemic exposure of bosentan, a drug approved for the treatment of pulmonary arterial hypertension, can be increased by bempedoic acid, since it is...