Summary Quinidine, procainamide and disopyramide are antiarrhythmic drugs in the class 1A category. These drugs have a low toxic to therapeutic ratio, and their use is associated with a number of serious adverse effects during long term therapy and life-threatening sequelae following acute overdose. ...
Although cardiac sodium channel blocking drugs can exert antiarrhythmic actions, they can also provoke life-threatening arrhythmias through a variety of mechanisms. This article addresses the way in which drugs interact with the channel and how these effects translate to clinical beneficial or detrimental...
Table 6.Possible DDIs of bempedoic acid and cardiovascular drugs. Safe co-administration can also be predicted with antiarrhythmic agents, while the systemic exposure of bosentan, a drug approved for the treatment of pulmonary arterial hypertension, can be increased by bempedoic acid, since it is ...