Quinidine, procainamide and disopyramide are antiarrhythmic drugs in the class 1A category. These drugs have a low toxic to therapeutic ratio, and their use is associated with a number of serious adverse effects during long term therapy and life-threatening sequelae following acute overdose. Class 1A...
Poisoning due to class 1A antiarrhythmic drugs. Quinidine, procainamide and disopyramide. Drug Saf 1990; 5: 393-420.Denaro CP, Benowitz NL. Poisoning due to class 1B antiarrhythmic drugs: lignocaine, mexiletine and tocainide. Med Toxicol Adverse Drug Exp 1989;4: 412-28....
Figure 4. Examples of class 1a antiarrhythmics. • Toxicity: Class 1a drugs all have subclass-wide adverse effects and toxicity profiles. They include ventricular arrhythmias and muscarinic antagonism, as well as nausea, vomiting, and diarrhea (in up to 30% of patients). Individual drugs can ...
M. Classifying antiarrhythmic actions: by facts or speculation. J. Clin. Pharmacol. 32, 964–977 (1992). 9. Milne, J. R. et al. Class 1 antiarrhythmic drugs—characteristic electrocardiographic differences when assessed by atrial and ventricular pacing. Eur. Heart J. 5, 99–107 (1984). ...
1993: Efficacy of class 1C antiarrhythmic agents in patients with inducible ventricular tachycardia refractory to therapy with class 1A antiarrhythmic drugs Journal of Clinical Pharmacology 33(7): 623-630 Allan, G.; Donoghue, S.; Follenfant, M.J.; Sawyer, D.A. 1986: BW A256C, a ...
Class IA drugsClass 1A agents share the electrophysiologic property of slmuing of V max of phase 0 of the action potential and moderate prolongation of the action potential duration and refractoriness. Their electrocardiographic effect in therapeutic doses is to prolong the QT c . interval due ...
The efficacy of class 1C antiarrhythmic agents was determined in 36 patients with inducible sustained monomorphic ventricular tachycardia during baseline electrophysiology study (EPS), who continued to have inducible monomorphic ventricular tachycardia during EPS on class 1A antiarrhythmic therapy. Of 12 ...
Belhassen, B., Viskin, S., Fish, R., et al., Effects of electrophysiologic-guided therapy with class 1A antiarrhythmic drugs on the long-term outcome of patients with idiopathic ventricular fibrillation with or without the Brugada syndrome. J. Cardiovasc. Electrophysiol. 10:1301–1312, 1999....
Management of Brugada Syndrome: Thirty-Three–Year Experience Using Electrophysiologically Guided Therapy With Class 1A Antiarrhythmic Drugs[J] . Bernard Belhassen,Michael Rahkovich,Yoav Michowitz,Aharon Glick,Sami Viskin.Circulation: Arrhythmia and Electrophysiology . 2015 (6)...
Management of Brugada Syndrome: Thirty-Three-Year Experience Using Electrophysiologically Guided Therapy With Class 1A Antiarrhythmic Drugs. Circ Arrhythm Electrophysiol 2015;8:1393-1402.Belhassen Bernard, RahkovichMichael, MichowitzYoav, GlickAharon, ViskinSami. Management of Brugada Syndrome: Thirty-...