In addition, CBD has the capacity to inhibit cytochrome P450 enzymes and uridine 5'-diphospho-glucuronosyltransferases, leading to potential drug-drug interactions with multiple common medications. The clinical significance of many of these interactions is also unclear. Furthermore, nonclinical studies ...
CYP2C19 metabolizes numerous commonly used drugs including citalopram, clomipramine, clopidogrel, diazepam, omeprazole, S-mephenytoin, and biguanides [97–99]. Approximately 2000 SNPs and more than 35 variants have been identified in the CYP2C19 gene. Among these polymorphisms, CYP2C19*2 and CYP2C19*...
No information on comedications with potential interactions with Escitalopram; The absence of exact information on the diagnosis and treatment outcomes, including the patients’ side effects, adherence, comorbidities, renal/liver function, Escitalopram continuation, and timing of drug switching. The above ...
interactions with other drugs [38,39], particularly in middle-aged women that frequently consume several drugs [23]. EE2was selected because it is an estrogen commonly used in ERT, is more potent than E2in reducing immobility behavior in the FST [40] and possesses a wider window of effect ...
Citalopram was chosen because of its wide use in clinical practice due to less pharmacokinetic interactions with other drugs [38,39], particularly in middle-aged women that frequently consume several drugs [23]. EE2 was selected because it is an estrogen commonly used in ERT, is more potent ...