Drug Interactions. Citalopram should not be taken while you are using certain other medicines. Before taking citalopram, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interacti...
Add a drug to check interactionsAdd Frequently asked questions View more FAQ Further information Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use citalopram only for the indication prescribed. ...
Citalopram is a weaker in vitro and in vivo inhibitor of the hepatic cytochrome P450 (CYP) 2D6 isozyme than paroxetine and fluoxetine and therefore has a lower potential for pharmacokinetic interactions with cytochrome CYP2D6 substrates such as tricyclic antidepressants and antipsychotic agents. ...
The maximum dose should also be limited to 20 mg once daily in patients with hepatic impairment and in patients who are greater than 60 years of age because of expected higher exposures [see Dosage and Administration (2.3, 2.4), Drug Interactions (7), Use in Specific Populations (8.5), ...
In addition, CBD has the capacity to inhibit cytochrome P450 enzymes and uridine 5'-diphospho-glucuronosyltransferases, leading to potential drug-drug interactions with multiple common medications. The clinical significance of many of these interactions is also unclear. Furthermore, nonclinical studies ...
We have previously shown that exposure to whole-body heating potentiates antidepressant-like behavioural responses following administration of a behaviourally subthreshold dose of the selective serotonin reuptake inhibitor citalopram, but the neurochemical and behavioural interactions between whole body heating ...
Of all of the SSRIs it has the least effect on the cytochrome P450 system and has the most favorable profile regarding drug–drug interactions. General Description Citalopram (Celexa) is a racemic mixture and is very SERTselective. The N-monodemethylated compound is slightlyless potent but is ...
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(see 5.01 The Why and How of Absorption, Distribution, Metabolism, Excretion, and Toxicity Research; 5.04 The Biology and Function of Transporters; 5.32 In Silico Models for Interactions with Transporters; 6.01 Central Nervous System Drugs Overview; 6.03 Affective Disorders: Depression and Bipolar ...
Apart from sleep medication (melatonin or diphenhydramine hydrochloride), concomitant treatment with psychotropic medications or medication having known interactions with citalopram was not permitted. Treatment Liquid citalopram (Celexa, 10 mg/5 mL) was obtained commercially. Placebo matched for smell, taste...