(See Interactions.)Maximum dosage of 20 mg daily in patients who are poor metabolizers of CYP2C19 and in patients receiving a CYP2C19 inhibitor, patients with hepatic impairment, and in patients >60 years of age since higher citalopram exposures increase risk of QT-interval prolongation and torsade...
Preliminary indications suggest that Citalopram may cause only moderate pharmacokinetic interactions or have no effect when coadministered with tricyclic antidepressants which are metabolised by CYP2D6, although formal studies of such interactions are limited. Available data suggest that coadministration of Ci...
The maximum dose should also be limited to 20 mg once daily in patients with hepatic impairment and in patients who are greater than 60 years of age because of expected higher exposures [see Dosage and Administration (2.3, 2.4), Drug Interactions (7), Use in Specific Populations (8.5), ...
Citalopram is a weaker in vitro and in vivo inhibitor of the hepatic cytochrome P450 (CYP) 2D6 isozyme than paroxetine and fluoxetine and therefore has a lower potential for pharmacokinetic interactions with cytochrome CYP2D6 substrates such as tricyclic antidepressants and antipsychotic agents. ...
The objective of this study is to characterize the effects of daily CBD use at a dose within the range of what consumers are taking as unapproved CBD products on liver enzyme elevations, drug interactions, and endocrine measures. 显示全部 开始日期2024-02-08 申办/合作机构 US Food & Drug ...
In addition, escitalopram has negligible effects on cytochrome P450 drug-metabolising enzymes in vitro, suggesting a low potential for drug-drug interactions. The efficacy of escitalopram in patients with major depressive disorder has been demonstrated in multiple short-term, placebo-controlled clinical ...
(see 5.01 The Why and How of Absorption, Distribution, Metabolism, Excretion, and Toxicity Research; 5.04 The Biology and Function of Transporters; 5.32 In Silico Models for Interactions with Transporters; 6.01 Central Nervous System Drugs Overview; 6.03 Affective Disorders: Depression and Bipolar ...
It is important to diagnose depression before prescribing Citka. Generic NameCitalopram Strength(s)10 mg Delivery25 days Brand Name Celexa Expiry Date2023 ShippingWorldwideSORRY! This Item Is Temporarily OUT OF STOCKIMPORTANT FEATURES Citka is a clinically proven and effective medicine for treating...
1000 µg/L. Fish were exposed in 25-L aquaria containing 10 L of the respective test solution, half of which was renewed twice a week. From the total yolk sac consumption until the end of the experiment, fish were fed daily 3% of body weight with commercial trout feed (first 0.5 mm...
However, coadministration of citalopram and the potent CYP3A4 inhibitor ketoconazole did not significantly affect the pharmacokinetics of citalopram [see Warnings and Precautions (5.2), Drug Interactions (7)]. Cimetidine In subjects who had received 21 days of 40 mg/day citalopram, combined ...